The protective effects of hesperidin and curcumin on 5-fluorouracil–induced nephrotoxicity in mice

V Gelen, E Şengül, S Yıldırım, E Senturk… - … Science and Pollution …, 2021 - Springer
Nephrotoxicity is a very important complication of 5-fluorouracil (5-FU)–treated cancer
patients. Increased oxidative stress, kidney damage, and apoptosis play an important role in …

Exploring the Multi-Faceted Potential of Carob (Ceratonia siliqua var. Rahma) Leaves from Morocco: A Comprehensive Analysis of Polyphenols Profile, Antimicrobial …

A Elbouzidi, M Taibi, H Ouassou, S Ouahhoud… - Pharmaceuticals, 2023 - mdpi.com
The botanical species Ceratonia siliqua L., commonly referred to as the Carob tree, and
locally as “L'Kharrûb”, holds significance as an agro-sylvo-pastoral species, and is …

A systematic review and meta‐analysis on the cardio‐protective activity of naringin based on pre‐clinical evidences

GL Viswanatha, H Shylaja, R Keni… - Phytotherapy …, 2022 - Wiley Online Library
The cardioprotective role of naringin has been scientifically well demonstrated in various
experimental models such as diabetic cardiomyopathy, ischemic heart diseases, diet …

Effects of naringin on oxidative stress, inflammation, some reproductive parameters, and apoptosis in acrylamide‐induced testis toxicity in rat

E Sengul, V Gelen, S Yildirim, İ Cinar… - Environmental …, 2023 - Wiley Online Library
Acrylamide (ACR) is used in many fields such as cosmetics, paper, and textile industries. It
also occurs at very high temperatures in some foods. Gonadotoxic effects of ACR have been …

Role of the renin-angiotensin-aldosterone system in various disease processes: An overview

V Gelen, A Kükürt, E Şengül - Renin-Angiotensin Aldosterone …, 2021 - books.google.com
The renin-angiotensin-aldosterone system is a physiological system that plays an important
role in the regulation of blood pressure and body water-electrolyte balance, in which the …

[HTML][HTML] Naringin attenuates oxidative stress, inflammation, apoptosis, and oxidative DNA damage in acrylamide-induced nephrotoxicity in rats

V Gelen, S Yıldırım, E Şengül, A Çınar… - Asian Pacific Journal …, 2022 - journals.lww.com
Objective: To explore the possible effects of naringin on acrylamide-induced nephrotoxicity
in rats. Methods: Sprague-Dawley rats weighing 200-250 g were randomly divided into five …

Nutritional value, HPLC-DAD analysis and biological activities of Ceratonia siliqua L. pulp based on in vitro and in silico studies

S Laaraj, A Tikent, C El-Rhouttais, A Farihi, A Ed-Dra… - Scientific Reports, 2024 - nature.com
The phytochemical, nutritional, and biological features of wild carob pulp from Tanzight (TN),
Ait-Waada (AW), and Tizi-ghnayn (TG) in Azilal were studied. The results of the study reveal …

Impact of polyethylene microplastics exposure on kallikrein-3 levels, steroidal-thyroidal hormones, and antioxidant status in murine model: protective potentials of …

SA Kehinde, TP Fatokun, AT Olajide, SM Praveena… - Scientific Reports, 2024 - nature.com
The widespread presence of microplastics in the environment has raised significant
concerns regarding their potential impact on human and animal health. Among various …

Cardioprotective activities of quercetin and rutin in Sprague Dawley rats treated with 5-fluorouracil.

E Sengul, V Gelen, S Gedikli - JAPS: Journal of Animal & …, 2021 - search.ebscohost.com
In this study, the protective effects of Quercetin (Q) and Rutin in 5-fluorouracil (5-FU)-induced
cardiotoxicity in rats were investigated and used eighty-piece Sprague Dawley male rats …

Cardioprotective effect of naringin against the ischemia/reperfusion injury of aged rats

D Shackebaei, M Hesari, S Ramezani-Aliakbari… - Naunyn-Schmiedeberg's …, 2024 - Springer
Aging is known as a main risk factor in the development of cardiovascular diseases.
Naringin (NRG) is a flavonoid compound derived from citrus fruits. It possesses a wide …