Exciting new discoveries have transformed the view of the lysosome from a static organelle
dedicated to the disposal and recycling of cellular waste to a highly dynamic structure that …

Neurons are markedly compartmentalized, which makes them reliant on axonal transport to
maintain their health. Axonal transport is important for anterograde delivery of newly …

The incidence of Alzheimer's disease (AD), the leading cause of dementia, increases rapidly
with age, but why age constitutes the main risk factor is still poorly understood. Brain ageing …

Mouse models of human diseases are invaluable tools for studying pathogenic mechanisms
and testing interventions and therapeutics. For disorders such as Alzheimer's disease in …

Neuritic plaques, a pathological hallmark in Alzheimer's disease (AD) brains, comprise
extracellular aggregates of amyloid-beta (Aβ) peptide and degenerating neurites that …

Alzheimer's disease (AD) remains one of the grand challenges facing human society. Much
controversy exists around the complex and multifaceted pathogenesis of this prevalent …

Complement pathway overactivation can lead to neuronal damage in various neurological
diseases. Although Alzheimer's disease (AD) is characterized by β-amyloid plaques and tau …

Many risk genes for the development of Alzheimer's disease (AD) are exclusively or highly
expressed in myeloid cells. Microglia are dependent on colony-stimulating factor 1 receptor …

Triggering receptor expressed on myeloid cells 2 (TREM2) plays crucial roles in Alzheimer's
disease (AD) by regulating microglia migration toward, and phagocytosis of oligomeric …

Extensive studies indicate that β-amyloid (Aβ) aggregation is pivotal for Alzheimer's disease
(AD) progression; however, cumulative evidence suggests that Aβ itself is not sufficient to …