Acute pancreatitis: diagnosis and treatment

P Szatmary, T Grammatikopoulos, W Cai, W Huang… - Drugs, 2022 - Springer
Acute pancreatitis is a common indication for hospital admission, increasing in incidence,
including in children, pregnancy and the elderly. Moderately severe acute pancreatitis with …

Severe hypertriglyceridaemia and chylomicronaemia syndrome—causes, clinical presentation, and therapeutic options

B Bashir, JH Ho, P Downie, P Hamilton, G Ferns… - Metabolites, 2023 - mdpi.com
We have reviewed the genetic basis of chylomicronaemia, the difference between
monogenic and polygenic hypertriglyceridaemia, its effects on pancreatic, cardiovascular …

[HTML][HTML] Hypertriglyceridemia-induced acute pancreatitis: A prospective, multicenter, international cohort analysis of 716 acute pancreatitis cases

D Mosztbacher, L Hanák, N Farkas, A Szentesi, A Mikó… - Pancreatology, 2020 - Elsevier
Background Hypertriglyceridemia is the third most common cause of acute pancreatitis (AP).
It has been shown that hypertriglyceridemia aggravates the severity and related …

Adding flexibility to clinical trial designs: an example-based guide to the practical use of adaptive designs

T Burnett, P Mozgunov, P Pallmann, SS Villar… - BMC medicine, 2020 - Springer
Adaptive designs for clinical trials permit alterations to a study in response to accumulating
data in order to make trials more flexible, ethical, and efficient. These benefits are achieved …

Baicalein alleviates pyroptosis and inflammation in hyperlipidemic pancreatitis by inhibiting NLRP3/Caspase-1 pathway through the miR-192-5p/TXNIP axis

X Wang, H Cai, Z Chen, Y Zhang, M Wu, X Xu… - International …, 2021 - Elsevier
Objective Hyperlipidemia is a main reason of pancreatitis. Baicalein can ameliorate the
pathological manifestations of pancreatitis. This study evaluated underlying molecular …

Comparable triglyceride reduction with plasma exchange and insulin in acute pancreatitis–a randomized trial

J Gubensek, M Andonova, A Jerman, V Persic… - Frontiers in …, 2022 - frontiersin.org
Background and Aims Both insulin and plasma exchange (PE) are used in
hypertriglyceridemic acute pancreatitis (HTG-AP). Our aim was to compare the efficacy of …

The role of apheresis and insulin therapy in hypertriglyceridemic acute pancreatitis—a concise review

J Gubensek - BMC gastroenterology, 2023 - Springer
Severe hypertriglyceridemia (HTG) is the third most common cause of acute pancreatitis
(AP) and is involved in its pathogenesis. Chylomicrons increase blood viscosity and induce …

Recent Treatment Strategies for Acute Pancreatitis

Y Song, SH Lee - Journal of clinical medicine, 2024 - mdpi.com
Acute pancreatitis (AP) is a leading gastrointestinal disease that causes hospitalization.
Initial management in the first 72 h after the diagnosis of AP is pivotal, which can influence …

Hyperlipemia pancreatitis onset time affects the association between elevated serum triglyceride levels and disease severity

X Dong, S Pan, D Zhang, W Hong, T Chen… - Lipids in Health and …, 2022 - Springer
Background The association of serum triglyceride (TG) levels with the severity of
hypertriglyceridaemia-induced acute pancreatitis (HTG-AP) remains controversial. This …

Insulin or blood purification treatment for hypertriglyceridaemia-associated acute pancreatitis: A systematic review and meta-analysis

W He, W Cai, X Yang, G Camilleri, X Zheng, Q Wang… - Pancreatology, 2022 - Elsevier
Background/objectives Hypertriglyceridaemia increases risks from acute pancreatitis (HTG-
AP) over other aetiologies, but optimal management for HTG-AP remains undefined. We …