Abstract Each year, about 5–6 cases out of 100,000 people are diagnosed with primary
malignant brain tumors, of which about 80% are malignant gliomas (MGs). Glioblastoma …

Glioblastoma (GBM) is the highest-grade form of glioma, as well as one of the most
aggressive types of cancer, exhibiting rapid cellular growth and highly invasive behavior …

Chemoresistant metastatic relapse of minimal residual disease plays a significant role for
poor prognosis of cancer. Growing evidence supports a critical role of cancer stem cell …

Abstract The effects of Jak Stat signaling and the persistent activation of Stat3 and Stat5 on
tumor cell survival, proliferation and invasion have made the Jak Stat pathway a favorite …

Despite maximal surgical and medical therapy, the treatment of glioblastoma remains a
seriously vexing problem, with median survival well under 2 years and few long-term …

The signal transducer and activator of transcription (STAT) proteins have important roles in
biological processes. The abnormal activation of STAT signalling pathways is also …

Simple Summary Glioblastoma is one of the most treatment-refractory human malignancies,
and despite techniques that have allowed scientists and clinicians to better understand the …

JAK-STAT is an efficient and highly regulated system mainly dedicated to the regulation of
gene expression. Primarily identified as functioning in hematopoietic cells, its role has been …

Glioblastoma (GBM) is the most prevalent primary brain tumor and ranks among the most
lethal of human cancers with conventional therapy offering only palliation. Great strides have …

Berberin, extracted from Chinese herbal medicine Coptis chinensis, has been found to have
anti-tumor activities. However, the underlying mechanisms have not been fully elucidated …