Physical forces and mechanical properties have critical roles in cellular function, physiology
and disease. Over the past decade, atomic force microscopy (AFM) techniques have …

The past decade has witnessed the accelerating development of immunotherapies for
cancer treatment. Immune checkpoint blockade therapies and chimeric antigen receptor …

During the last three decades, a series of key technological improvements turned atomic
force microscopy (AFM) into a nanoscopic laboratory to directly observe and chemically …

Significance: Particulate matter (PM) air pollution is a leading cause of global cardiovascular
morbidity and mortality. Understanding the biological action of PM is of particular importance …

Purpose The aims of this article were to systematically review the literature about the
mechanism of action of colchicine in the multimodal pathology of acute inflammation …

Vaccines aim to protect against or treat diseases through manipulation of the immune
response, promoting either immunity or tolerance. In the former case, vaccines generate …

Inflammation In the absence of pathogens occurs in all tissues in response to a wide range
of stimuli that cause tissue stress and injury. Such sterile inflammation (SI) is a key process …

Spleen tyrosine kinase (SYK) is known to have a crucial role in adaptive immune receptor
signalling. However, recent reports indicate that SYK also mediates other, unexpectedly …

Phagocytosis—the process by which macrophages, dendritic cells and other myeloid
phagocytes internalize diverse particulate targets—is a key mechanism of innate immunity …

Uric acid is a waste product of purine catabolism. This molecule comes to clinical attention
when it nucleates to form crystals of monosodium urate (MSU) in joints or other tissues, and …