Homologous recombination (HR) is a major pathway for the repair of DNA double-strand
breaks in mammalian cells, the defining step of which is homologous strand exchange …

In the last two decades, an increasing amount of studies have investigated the use of
components based on carbon-(nano) materials in the engineering of neural interfaces, to …

Background Rucaparib, a poly (ADP-ribose) polymerase inhibitor, has anticancer activity in
recurrent ovarian carcinoma harbouring a BRCA mutation or high percentage of genome …

The process of homologous recombination is a major DNA repair pathway that operates on
DNA double-strand breaks, and possibly other kinds of DNA lesions, to promote error-free …

Homologous recombination (HR) is a pathway to faithfully repair DNA double-strand breaks
(DSBs). At the core of this pathway is a DNA recombinase, which, as a nucleoprotein …

RAD51C is an enigmatic predisposition gene for breast, ovarian, and prostate cancer.
Currently, missing structural and related functional understanding limits patient mutation …

The accurate repair of DNA is critical for genome stability and cancer prevention. DNA
double-strand breaks are one of the most toxic lesions; however, they can be repaired using …

Background In ARIEL3, rucaparib maintenance treatment significantly improved progression-
free survival versus placebo. Here, we report prespecified, investigator-assessed …

Numerous agents of endogenous and exogenous origin damage DNA in our genome.
There are several DNA‐repair pathways that recognize lesions in DNA and remove them …

Cells defective in any of the RAD51 paralogs (RAD51B, RAD51C, RAD51D, XRCC2, and
XRCC3) are sensitive to DNA cross-linking agents and to ionizing radiation. Because the …