Vitamin D is a fat-soluble secosteroid, traditionally considered a key regulator of bone
metabolism, calcium and phosphorous homeostasis. Its action is made possible through the …

Background: Emerging evidence suggests the potential relationship between vitamin D
deficiency and risk of cognitive impairment or dementia. To what extent the excess risk of …

Vitamin D receptor (VDR) is an essential transcription factor (TF) synthesized in different cell
types. We hypothesized that VDR might also act as a mitochondrial TF. We conducted the …

Our recent study indicated that vitamin D and its receptors are important parts of the amyloid
processing pathway in neurons. Yet the role of vitamin D receptor (VDR) in amyloid …

The purpose of the study was to investigate the role of vitamin D binding protein (VDBP,
DBP) and its polymorphism in the vitamin D pathway and human health. This narrative …

The challenge of understanding the biology of neuronal amyloid processing could provide a
basis for understanding the amyloid pathology in Alzheimer's disease (AD). Based on our …

Alzheimer's disease (AD) is a progressive neurodegenerative disorder seen mostly in the
elderly population. While to date AD research has focused on either neurochemical …

Vitamin D is a secosteroid hormone that shares a synthetic pathway with cholesterol. ApoE,
which is involved in the transport of cholesterol, is the most significant genetic risk factor for …

Vitamin D, a secosteroid hormone, has, over the years, mainly been known for its classic
role in the maintenance of calcium homeostasis of the human body. However, there is …

Vitamin D is a secosteroid hormone exerting neurosteroid-like properties. Its well-known
nuclear hormone receptor, and recently proposed as a mitochondrial transcription factor …