Autism spectrum disorders (ASDs) and related neurological disorders are associated with
mutations in many genes affecting the ratio between neuronal excitation and inhibition …

GABAergic inhibition shapes the connectivity, activity and plasticity of the brain. A series of
exciting new discoveries provides compelling evidence that disruptions in a number of key …

Rett syndrome (RTT) is a severe neurological disorder caused by mutations in the X-linked
gene MECP2 (methyl-CpG-binding protein 2). Two decades of research have fostered the …

Autism spectrum disorder (ASD) refers to a series of neurodevelopmental diseases
characterized by two hallmark symptoms, social communication deficits and repetitive …

In physiological conditions, adult neurons have low intracellular Cl−[(Cl−) I] levels
underlying the γ-aminobutyric acid (GABA) ergic inhibitory drive. In contrast, neurons have …

In the 50 years since Andreas Rett first described the syndrome that came to bear his name,
and is now known to be caused by a mutation in the methyl-CpG-binding protein 2 (MECP2) …

Brain function relies on the ability of neural networks to maintain stable levels of activity,
while experiences sculpt them. In the neocortex, the balance between activity and stability …

Rett syndrome (RTT) arises from loss-of-function mutations in methyl-CpG binding protein 2
gene (Mecp2), but fundamental aspects of its physiological mechanisms are unresolved …

There is an increasing recognition of clinical overlap in patients presenting with epilepsy
and autism spectrum disorder (ASD), and a great deal of new information regarding the …

Amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD) are overlapping
neurodegenerative disorders whose pathogenesis remains largely unknown. Using TDP-43 …