Drug delivery systems, CNS protection, and the blood brain barrier

RK Upadhyay - BioMed research international, 2014 - Wiley Online Library
Present review highlights various drug delivery systems used for delivery of pharmaceutical
agents mainly antibiotics, antineoplastic agents, neuropeptides, and other therapeutic …

Peptide conjugation via CuAAC 'click'chemistry

AAH Ahmad Fuaad, F Azmi, M Skwarczynski, I Toth - Molecules, 2013 - mdpi.com
The copper (I)-catalyzed alkyne azide 1, 3-dipolar cycloaddition (CuAAC) or 'click'reaction, is
a highly versatile reaction that can be performed under a variety of reaction conditions …

Recent trends in bioorthogonal click-radiolabeling reactions using fluorine-18

M Pretze, D Pietzsch, C Mamat - Molecules, 2013 - mdpi.com
The increasing application of positron emission tomography (PET) in nuclear medicine has
stimulated the extensive development of a multitude of novel and versatile bioorthogonal …

Imaging the tumor microenvironment

MCZ Abadjian, WB Edwards, CJ Anderson - … Immune Microenvironment in …, 2017 - Springer
The tumor microenvironment consists of tumor, stromal, and immune cells, as well as
extracellular milieu. Changes in numbers of these cell types and their environments have an …

18F‐Labeling Using Click Cycloadditions

K Kettenbach, H Schieferstein… - BioMed research …, 2014 - Wiley Online Library
Due to expanding applications of positron emission tomography (PET) there is a demand for
developing new techniques to introduce fluorine‐18 (t1/2= 109.8 min). Considering that …

Radiosynthesis of [18F]Trifluoroalkyl Groups: Scope and Limitations

VT Lien, PJ Riss - BioMed Research International, 2014 - Wiley Online Library
Radiosynthesis of [18F]Trifluoroalkyl Groups: Scope and Limitations - Lien - 2014 - BioMed
Research International - Wiley Online Library Skip to Article Content Skip to Article …

Imaging the proangiogenic effects of cardiovascular drugs in a diabetic model of limb ischemia

JL Goggi, A Haslop, R Boominathan… - Contrast media & …, 2019 - Wiley Online Library
Purpose. Peripheral artery disease (PAD) causes narrowing of arteries in the limbs, leading
to tissue ischemia, gangrene, and eventually limb amputation. The presence of diabetes …

18F‐Labelled Intermediates for Radiosynthesis by Modular Build‐Up Reactions: Newer Developments

J Ermert - BioMed research international, 2014 - Wiley Online Library
This brief review gives an overview of newer developments in 18F‐chemistry with the focus
on small 18F‐labelled molecules as intermediates for modular build‐up syntheses. The …

Imaging Fibrogenesis in a Diet‐Induced Model of Nonalcoholic Steatohepatitis (NASH)

SV Hartimath, R Boominathan, V Soh… - Contrast Media & …, 2019 - Wiley Online Library
Purpose. Liver fibrosis is the hallmark of chronic nonalcoholic steatohepatitis (NASH) and is
characterised by the excessive deposition of extracellular matrix proteins. Early detection …

Stratification of 18F-labeled PET imaging agents for the assessment of antiangiogenic therapy responses in tumors

JL Goggi, R Bejot, SS Moonshi… - Journal of Nuclear …, 2013 - Soc Nuclear Med
Successful antiangiogenic therapies have been developed for the treatment of various
cancers, but not all patients respond. Therefore, the early determination of therapy efficacy is …