Recent data have expanded the concept that inflammation is a critical component of tumour
progression. Many cancers arise from sites of infection, chronic irritation and inflammation. It …

ABSTRACT GM-CSF was originally defined by its ability to generate in vitro granulocyte and
macrophage colonies from bone marrow precursor cells. Apart from its physiological role in …

Dendritic cells (DC) were cultured from mouse bone marrow (BM) progenitors in low
concentrations of granulocyte‐macrophage colony‐stimulating factor (GM‐CSF)(GMlo DC) …

This study shows that a corpus of proto-word forms shares four sequential sound patterns
with words of modern languages and the first words of infants. Three of the patterns involve …

Major histocompatibility complex class II (MHC II) molecules capture peptides within the
endocytic pathway to generate T cell receptor (TCR) ligands. Immature dendritic cells (DCs) …

Innate immune system activation is a critical step in the initiation of an effective adaptive
immune response; therefore, activation of a class of innate pathogen receptors called …

Bone marrow derived dendritic cells (BMDCs) are routinely employed in cell based assays
to evaluate immunomodulatory and anti-inlammatory activities. Hence, simplified, stepwise …

Background. Dendritic cells secrete a population of “antigen-presenting vesicles,” called
exosomes, expressing functional class I and II major histocompatibility complex (MHC) and …

A variety of extraimmune system factors, including hormones, play a critical role in regulating
immunity. Progesterone has been shown to affect immunity in rodents and humans, mainly …

Dendritic cell (DC) vaccine–based immunotherapy for glioblastoma multiforme (GBM) has
shown apparent benefit in animal experiments and early-phase clinical trials, but the …