Many molecular, physiological and behavioural processes display distinct 24-hour rhythms
that are directed by the circadian system. The master clock, located in the suprachiasmatic …

Evidence is accumulating regarding the importance of circadian core oscillators, several
associated factors, and melatonin signaling in the maintenance of health. Dysfunction of …

Melatonin is a pleiotropically acting regulator molecule, which influences numerous
physiological functions. Its secretion by the pineal gland progressively declines by age …

Melatonin is a hormone secreted by the pineal gland in accordance with the circadian
rhythm when the light level decreases. Reduction of melatonin secretion with age may be …

Over recent years, a deeper comprehension of the molecular mechanisms that control
biological clocks and circadian rhythms has been achieved. In fact, many studies have …

In mammals, molecular circadian clocks are present in most cells of the body, and this
circadian network plays an important role in synchronizing physiological processes and …

Dynamic aspects of melatonin's actions merit increasing future attention. This concerns
particularly entirely different effects in senescent, weakened oscillators and in dysregulated …

People with autism spectrum disorder (ASD) commonly experience other comorbidities.
Studies indicate that between 50% and 83% of individuals with ASD have sleep problems or …

The dramatic fluctuations in energy demands by the rhythmic succession of night and day on
our planet has prompted a geophysical evolutionary need for biological temporal …

Most of the genetic variation associated with diabetes, through genome-wide association
studies, does not reside in protein-coding regions, making the identification of functional …