Neuronal plasticity: beyond the critical period

M Hübener, T Bonhoeffer - Cell, 2014 - cell.com
Neuronal plasticity in the brain is greatly enhanced during critical periods early in life and
was long thought to be rather limited thereafter. Studies in primary sensory areas of the …

Mechanisms underlying the role of DISC1 in synaptic plasticity

D Tropea, N Hardingham, K Millar… - The Journal of …, 2018 - Wiley Online Library
Abstract Disrupted in schizophrenia 1 (DISC1) is an important hub protein, forming
multimeric complexes by self‐association and interacting with a large number of synaptic …

Mouse vision as a gateway for understanding how experience shapes neural circuits

NJ Priebe, AW McGee - Frontiers in Neural Circuits, 2014 - frontiersin.org
Genetic programs controlling ontogeny drive many of the essential connectivity patterns
within the brain. Yet it is activity, derived from the experience of interacting with the world …

Distinct laminar requirements for NMDA receptors in experience-dependent visual cortical plasticity

M Fong, PS Finnie, T Kim, A Thomazeau… - Cerebral …, 2020 - academic.oup.com
Primary visual cortex (V1) is the locus of numerous forms of experience-dependent plasticity.
Restricting visual stimulation to one eye at a time has revealed that many such forms of …

Investigating female versus male differences in white matter neuroplasticity associated with complex visuo-motor learning

ED Kirby, JW Andrushko, S Rinat, RCN D'Arcy… - Scientific Reports, 2024 - nature.com
Magnetic resonance imaging (MRI) has increasingly been used to characterize structure–
function relationships during white matter neuroplasticity. Biological sex differences may be …

Blockade of GluN2B-containing NMDA receptors prevents potentiation and depression of responses during ocular dominance plasticity

MCD Bridi, S Hong, D Severin, C Moreno… - Journal of …, 2024 - jneurosci.org
Monocular deprivation (MD) causes an initial decrease in synaptic responses to the
deprived eye in juvenile mouse primary visual cortex (V1) through Hebbian long-term …

Major vault protein, a candidate gene in 16p11. 2 microdeletion syndrome, is required for the homeostatic regulation of visual cortical plasticity

JPK Ip, I Nagakura, J Petravicz, K Li… - Journal of …, 2018 - Soc Neuroscience
Microdeletion of a region in chromosome 16p11. 2 increases susceptibility to autism.
Although this region contains exons of 29 genes, disrupting only a small segment of the …

Astrocyte and neuronal plasticity in the somatosensory system

RE Sims, JB Butcher, HR Parri, S Glazewski - Neural plasticity, 2015 - Wiley Online Library
Changing the whisker complement on a rodent's snout can lead to two forms of experience‐
dependent plasticity (EDP) in the neurons of the barrel cortex, where whiskers are …

Top-down suppression of sensory cortex in an NMDAR hypofunction model of psychosis

A Ranson, E Broom, A Powell, F Chen… - Schizophrenia …, 2019 - academic.oup.com
Conceptual and computational models have been advanced that propose that perceptual
disturbances in psychosis, such as hallucinations, may arise due to a disruption in the …

Do cortical plasticity mechanisms differ between males and females?

J Dachtler, K Fox - Journal of Neuroscience Research, 2017 - Wiley Online Library
The difference between male and female behavior and male and female susceptibility to a
number of neuropsychiatric conditions is not controversial. From a biological perspective …