In mammals, the white adipocyte is a cell type that is specialized for storage of energy (in the
form of triacylglycerols) and for energy mobilization (as fatty acids). White adipocyte …

Technical advances at the interface of biology and computation, such as single-cell RNA-
sequencing (scRNA-seq), reveal new layers of complexity in cellular systems. An emerging …

White to brown/beige adipocytes conversion is a possible therapeutic strategy to tackle the
current obesity epidemics. While mitochondria are key for energy dissipation in brown fat, it …

Adaptive thermogenesis by brown adipose tissue (BAT) dissipates calories as heat, making
it an attractive anti-obesity target. Yet how BAT contributes to circulating metabolite …

Active brown adipose tissue (BAT) consumes copious amounts of glucose, yet how glucose
metabolism supports thermogenesis is unclear. By combining transcriptomics …

Abstract Background and Objectives: Genome-scale metabolic networks (GEMs) represent a
valuable modeling and computational tool in the broad field of systems biology. Their ability …

Lycopene (LYC), one of the major carotenoids in tomatoes, has been preclinically and
clinically used to obesity and type 2 diabetes management. However, whether its ability of …

Constraint‐based modeling methods, such as Flux Balance Analysis (FBA), have been
extensively used to decipher complex, information rich‐omics datasets to elicit system‐wide …

Brown adipocytes are highly specialized cells with the unique metabolic ability to dissipate
chemical energy in the form of heat. We determined and inferred the flux of a number of key …

The model xeno-estrogen bisphenol A (BPA) has been extensively studied over the past two
decades, contributing to major advances in the field of endocrine disrupting chemicals …