Towards precision medicine in non-alcoholic fatty liver disease

SM Francque - Reviews in Endocrine and Metabolic Disorders, 2023 - Springer
Abstract Non-Alcoholic Fatty Liver Disease (NAFLD) refers to the accumulation of lipid laden
vacuoles in hepatocytes, occurring in the context of visceral adiposity, insulin resistance and …

Genetics of MASLD: The State of Art Update.

S Sookoian, Y Rotman, L Valenti - Clinical Gastroenterology and …, 2024 - Elsevier
Recent advances in the genetics of metabolic dysfunction-associated steatotic liver disease
(MASLD) are gradually revealing the mechanisms underlying the heterogeneity of the …

[HTML][HTML] Familial coaggregation of MASLD with hepatocellular carcinoma and adverse liver outcomes: Nationwide multigenerational cohort study

F Ebrahimi, H Hagström, J Sun, D Bergman… - Journal of …, 2023 - Elsevier
Background & Aims Metabolic dysfunction-associated steatotic liver disease (MASLD;
formerly NAFLD) is the fastest growing cause of hepatocellular carcinoma (HCC) worldwide …

Impact of PNPLA3 rs738409 polymorphism on the development of liver-related events in patients with nonalcoholic fatty liver disease

C Rosso, GP Caviglia, G Birolo, A Armandi… - Clinical …, 2023 - Elsevier
Abstract Background and Aims Nonalcoholic fatty liver disease (NAFLD) is a complex
disease, resulting from the interplay between environmental determinants and genetic …

[HTML][HTML] Identification and characterisation of a rare MTTP variant underlying hereditary non-alcoholic fatty liver disease

JI Grove, PCK Lo, N Shrine, J Barwell, LV Wain… - JHEP Reports, 2023 - Elsevier
Abstract Background & Aims Non-alcoholic fatty liver disease (NAFLD) is a complex trait with
an estimated prevalence of 25% globally. We aimed to identify the genetic variant …

PNPLA3 I148M and response to treatment for hepatic steatosis: A systematic review

J Boeckmans, A Gatzios, JM Schattenberg… - Liver …, 2023 - Wiley Online Library
Background It is unclear whether the patatin‐like phospholipase domain‐containing protein
3 (PNPLA3) rs738409 C‐to‐G single nucleotide polymorphism, resulting in the substitution …

[HTML][HTML] Prevalence and determinants of liver disease in relatives of Italian patients with advanced MASLD

S Pelusi, L Ronzoni, J Rondena, C Rosso… - Clinical …, 2024 - Elsevier
Background & Aims Metabolic dysfunction associated steatotic liver disease (MASLD) has a
strong genetic component. The aim of this study was to examine noninvasively the …

The Role of Exercise in Steatotic Liver Diseases: An Updated Perspective

I Alabdul Razzak, A Fares, JG Stine… - Liver …, 2025 - Wiley Online Library
Background The increasing prevalence of metabolic dysfunction‐associated steatotic liver
disease (MASLD), formerly known as non‐alcoholic fatty liver disease (NAFLD), parallels …

The link between liver fat and cardiometabolic diseases is highlighted by genome-wide association study of MRI-derived measures of body composition

D van der Meer, TP Gurholt, IE Sønderby… - Communications …, 2022 - nature.com
Obesity and associated morbidities, metabolic associated fatty liver disease (MAFLD)
included, constitute some of the largest public health threats worldwide. Body composition …

Diagnostic scores and scales for appraising Nonalcoholic fatty liver disease and omics perspectives for precision medicine

N Perez-Diaz-del-Campo… - Current Opinion in …, 2022 - journals.lww.com
The growing NAFLD pandemic urges clinicians to seek alternatives for screening, early
diagnosis, and follow-up, especially for those with contraindications for liver biopsy. New …