Agmatine, an endogenous polyamine derived from L-arginine, elicits tremendous
multimodal neuromodulant properties. Alterations in agmatinergic signalling are closely …

This paper is the thirty-seventh consecutive installment of the annual review of research
concerning the endogenous opioid system. It summarizes papers published during 2014 …

Agmatine, the decarboxylation product of arginine, was largely neglected as an important
player in mammalian metabolism until the mid-1990s, when it was re-discovered as an …

Background: Epilepsy is a common neurological disease, and neuroinflammation is one of
the main contributors to epileptogenesis. Pyroptosis is a type of pro-inflammatory cell death …

Neurological disorders result in disability and morbidity. Neuroinflammation is a key factor
involved in progression or resolution of a series of neurological disorders like Huntington …

Ivermectin (IVM) is an antiparasitic drug that primarily works by the activation of GABAA
receptors. The potential pharmacological pathways behind the anti-convulsant effect of IVM …

Purpose Diabetes mellitus (DM) and epilepsy and the psychological and socio-economic
implications that are associated with their treatments can be quite perplexing. Metformin is …

Cannabinoid and PPAR receptors show well established interactions in a set of
physiological effects. Regarding the seizure-modulating properties of both classes of …

Epilepsy is fourth most common neurological disorders associated with depression and
cognitive deficits. As per present scenario, none of the antiseizure drugs have been reported …

Licofelone is a COX/5-LOX inhibitor, which recently was approved as an effective treatment
for osteoarthritis. Beside its analgesic and anti-inflammatory effects, some reports show …