Breast cancer in the era of integrating “Omics” approaches
C Rossi, I Cicalini, MC Cufaro, A Consalvo… - Oncogenesis, 2022 - nature.com
Worldwide, breast cancer is the leading cause of cancer-related deaths in women. Breast
cancer is a heterogeneous disease characterized by different clinical outcomes in terms of …
cancer is a heterogeneous disease characterized by different clinical outcomes in terms of …
Proteomics-based identification of dysregulated proteins in breast cancer
Immunohistochemistry (IHC) is still widely used as a morphology-based assay for in situ
analysis of target proteins as specific tumor antigens. However, as a very heterogeneous …
analysis of target proteins as specific tumor antigens. However, as a very heterogeneous …
Uncoupled glycerol-3-phosphate shuttle in kidney cancer reveals that cytosolic GPD is essential to support lipid synthesis
Summary The glycerol-3-phosphate shuttle (G3PS) is a major NADH shuttle that
regenerates reducing equivalents in the cytosol and produces energy in the mitochondria …
regenerates reducing equivalents in the cytosol and produces energy in the mitochondria …
Expression of lipid-metabolism genes is correlated with immune microenvironment and predicts prognosis in osteosarcoma
H Qian, T Lei, Y Hu, P Lei - Frontiers in cell and developmental …, 2021 - frontiersin.org
Objectives Osteosarcoma was the most popular primary malignant tumor in children and
adolescent, and the 5-year survival of osteosarcoma patients gained no substantial …
adolescent, and the 5-year survival of osteosarcoma patients gained no substantial …
The endocannabinoid system as a pharmacological target for new cancer therapies
R Ramer, F Wittig, B Hinz - Cancers, 2021 - mdpi.com
Simple Summary Cannabinoids have been shown to suppress tumour cell proliferation,
tumour invasion, metastasis, angiogenesis, chemoresistance and epithelial-mesenchymal …
tumour invasion, metastasis, angiogenesis, chemoresistance and epithelial-mesenchymal …
Proteomics-Based identification of dysregulated proteins and biomarker discovery in invasive ductal carcinoma, the most common breast cancer subtype
Invasive ductal carcinoma (IDC) is the most common histological subtype of malignant
breast cancer (BC), and accounts for 70–80% of all invasive BCs. IDC demonstrates great …
breast cancer (BC), and accounts for 70–80% of all invasive BCs. IDC demonstrates great …
Identification of potential modulators for human GPD1 by docking-based virtual screening, molecular dynamics simulations, binding free energy calculations, and …
A Hu, H Chen, W Pang, X Pu, Z Qi, H Chen - Scientific Reports, 2024 - nature.com
Abstract Cytosolic Glycerol-3-phosphate dehydrogenase 1 (GPD1, EC 1.1. 1.8) plays a
pivotal role in regulating the Embden-Meyerhof glucose glycolysis pathway (EM pathway) …
pivotal role in regulating the Embden-Meyerhof glucose glycolysis pathway (EM pathway) …
GPD1 inhibits the carcinogenesis of breast cancer through increasing PI3K/AKT-mediated lipid metabolism signaling pathway
Z Xia, N Zhao, M Liu, DD Jiang, S Gao, P Ma, L Huang - Heliyon, 2023 - cell.com
Abstract Glycerol 3-phosphate dehydrogenase 1 (GPD1) acts as a tumor suppressor in
various types of cancer. However, the mechanisms of GPD1 anti-tumor remain unclear in …
various types of cancer. However, the mechanisms of GPD1 anti-tumor remain unclear in …
Multi-omic approaches to breast cancer metabolic phenotyping: Applications in diagnosis, prognosis, and the development of novel treatments
N Gómez-Cebrián, I Domingo-Ortí, JL Poveda… - Cancers, 2021 - mdpi.com
Simple Summary Breast cancer (BC) is a heterogeneous tumor type and has become the
leading cause of cancer worldwide, with 685,000 deaths forecast in 2020. The clinical …
leading cause of cancer worldwide, with 685,000 deaths forecast in 2020. The clinical …
Prognostic value of a novel glycolysis-related gene expression signature for gastrointestinal cancer in the Asian population
R Xia, H Tang, J Shen, S Xu, Y Liang, Y Zhang… - Cancer Cell …, 2021 - Springer
Background Globally, gastrointestinal (GI) cancer is one of the most prevalent malignant
tumors. However, studies have not established glycolysis-related gene signatures that can …
tumors. However, studies have not established glycolysis-related gene signatures that can …