Guidelines for experimental models of myocardial ischemia and infarction

ML Lindsey, R Bolli, JM Canty Jr… - American Journal …, 2018 - journals.physiology.org
Myocardial infarction is a prevalent major cardiovascular event that arises from myocardial
ischemia with or without reperfusion, and basic and translational research is needed to …

Practical guidelines for rigor and reproducibility in preclinical and clinical studies on cardioprotection

HE Bøtker, D Hausenloy, I Andreadou… - Basic research in …, 2018 - Springer
The potential for ischemic preconditioning to reduce infarct size was first recognized more
than 30 years ago [180]. Despite extension of the concept to ischemic postcondition‑ing …

Statistical considerations in reporting cardiovascular research

ML Lindsey, GA Gray, SK Wood… - American Journal of …, 2018 - journals.physiology.org
The problem of inadequate statistical reporting is long standing and widespread in the
biomedical literature, including in cardiovascular physiology. Although guidelines for …

Current status and limitations of myocardial infarction large animal models in cardiovascular translational research

HS Shin, HH Shin, Y Shudo - Frontiers in bioengineering and …, 2021 - frontiersin.org
Establishing an appropriate disease model that mimics the complexities of human
cardiovascular disease is critical for evaluating the clinical efficacy and translation success …

[HTML][HTML] Large animal models of cardiac ischemia-reperfusion injury: Where are we now?

A Rahman, Y Li, TK Chan, H Zhao, Y Xiang… - Zoological …, 2023 - ncbi.nlm.nih.gov
Large animal models of cardiac ischemia-reperfusion are critical for evaluation of the
efficacy of cardioprotective interventions prior to clinical translation. Nonetheless, current …

Myocardial infarction from a tissue engineering and regenerative medicine point of view: A comprehensive review on models and treatments

G Basara, G Bahcecioglu, SG Ozcebe, BW Ellis… - Biophysics …, 2022 - pubs.aip.org
In the modern world, myocardial infarction is one of the most common cardiovascular
diseases, which are responsible for around 18 million deaths every year or almost 32% of all …

A novel method for the percutaneous induction of myocardial infarction by occlusion of small coronary arteries in the rabbit

M Freeman, E Huethorst, E Boland… - American Journal …, 2024 - journals.physiology.org
Arrhythmic sudden cardiac death (SCD) is an important cause of mortality following
myocardial infarction (MI). The rabbit has similar cardiac electrophysiology to humans and is …

A universal scaling relation for defining power spectral bands in mammalian heart rate variability analysis

JA Behar, AA Rosenberg, O Shemla… - Frontiers in …, 2018 - frontiersin.org
Background: Power spectral density (PSD) analysis of the heartbeat intervals in the three
main frequency bands [very low frequency (VLF), low frequency (LF), and high frequency …

Beating rate variability of isolated mammal sinoatrial node tissue: insight into its contribution to heart rate variability

O Shemla, K Tsutsui, JA Behar, Y Yaniv - Frontiers in neuroscience, 2021 - frontiersin.org
Background Because of the complexity of the interaction between the internal pacemaker
mechanisms, cell interconnected signals, and interaction with other body systems, study of …

Myofibroblast senescence promotes arrhythmogenic remodeling in the aged infarcted rabbit heart

BC Baggett, KR Murphy, E Sengun, E Mi, Y Cao… - Elife, 2023 - elifesciences.org
Progressive tissue remodeling after myocardial infarction (MI) promotes cardiac arrhythmias.
This process is well studied in young animals, but little is known about pro-arrhythmic …