The Hutchinson–Gilford progeria syndrome (HGPS) is a premature aging disease caused by
mutations of the LMNA gene leading to increased production of a partially processed form of …

One of the main factors associated with worse prognosis in oncology is metastasis, which is
based on the ability of tumor cells to migrate from the primary source and to form secondary …

The nuclear lamina serves important roles in chromatin organization and structural support,
and lamina mutations can result in laminopathies. Less is known about how nuclear lamina …

The nuclear lamina (NL) lines the nuclear envelope (NE) to maintain nuclear structure in
metazoan cells. The major NL components, the nuclear lamins contribute to the protection …

A-and B-type lamins are type V intermediate filament proteins. Mutations in the genes
encoding these lamins cause rare diseases, collectively called laminopathies. A fraction of …

Micronuclei (MN) are a commonly used marker of chromosome instability that form when
missegregated chromatin recruits its own nuclear envelope (NE) after mitosis. MN frequently …

The nuclear lamina (NL) lines the nuclear envelope (NE) to maintain nuclear structure in
metazoan cells. The major NL components, the nuclear lamins contribute to the protection …

Lamins are type V intermediate filaments that collectively form a meshwork underneath the
inner nuclear membrane, called nuclear lamina. Furthermore, they are also present in the …

Storing and regulating the cell's genetic material is a complex process vital to maintaining
proper cell function and, in eukaryotes, the nucleus is largely responsible for this process …

Жесткий скелет, сформированный сетями ламинов типов А и В, отвечает за
поддержание формы ядра. Более того, изменение соотношения белковrламинов в его …