The brain is the key organ of the response to stress because it determines what is
threatening and, therefore, potentially stressful, as well as the physiological and behavioral …

The microbiota–gut–brain axis plays an important role in the development of
neurodegenerative diseases. Commensal and pathogenic enteric bacteria can influence …

Adolescence represents a critical period for brain and behavioural health and characterised
by the onset of mood, psychotic and anxiety disorders. In rodents, neurogenesis is very …

Corticotropin-releasing hormone (CRH) plays a central role in the regulation of the
hypothalamic-pituitary-adrenal (HPA)-axis, ie, the final common pathway in the stress …

We recently demonstrated that stress-induced cognitive deficits in rats do not correlate with
hippocampal neuronal loss. Working on the premise that subtle structural changes may …

The hippocampus, a limbic structure important in learning and memory, is particularly
sensitive to chronic stress and to glucocorticoids. While glucocorticoids are essential for an …

Stress can exert long-lasting changes on the brain that contribute to vulnerability to mental
illness, yet mechanisms underlying this long-term vulnerability are not well understood. We …

Adolescence is a critical period for brain maturation. Deciphering how disturbances to the
central nervous system at this time affect structure, function and behavioural outputs is …

Background: Reduced brain-derived neurotrophic factor (BDNF) levels have been reported
in the serum and plasma of patients with psychosis. The aim of this cross-sectional case …

Repeated stress is an important risk factor for the development of depression. However, the
mechanism by which stress influences depression is largely unknown, in part due to the fact …