Background The impact of precision psychiatry for clinical practice has not been
systematically appraised. This study aims to provide a comprehensive review of validated …

Background: Primary prevention has the potential to modify the course of depression, but the
consistency and magnitude of this effect are currently undetermined. Methods: PRISMA and …

Introduction No systematic review has estimated the consistency and the magnitude of the
risk of developing bipolar disorder I-II (BD-I/II) in individuals at clinical high risk for bipolar …

Lithium remains an effective option in the treatment of bipolar disorder (BD). Thus, we aim to
characterize the pharmaco-epidemiological patterns of lithium use internationally over time …

Objective: Depression is one of the most prevalent and disabling mental health conditions
among young people worldwide. The health and economic burdens associated with …

Background Early detection of prodromal symptoms may contribute to improving the
prognosis of patients with bipolar disorder (BD). The main objective of this systematic review …

Background A growing body of evidence suggests that pediatric bipolar disorder (PBD)
frequently cooccurs with comorbid psychiatric disorders that may impact functioning …

Background Poor sleep is prevalent in adolescents with bipolar disorder, precedes illness
onset, and is associated with worse mood symptoms. We examined interrelationships …

Virtual reality (VR) is a technology that allows to interact with recreated digital environments
and situations with enhanced realism. VR has shown good acceptability and promise in …

Objectives We aimed to investigate the characteristics of adolescents with Bipolar disorder-I
with irritability and agitation (Mania+ IA) compared to those without irritability and agitation …