Antimicrobial host defence peptides: functions and clinical potential

N Mookherjee, MA Anderson, HP Haagsman… - Nature reviews Drug …, 2020 - nature.com
Cationic host defence peptides (CHDP), also known as antimicrobial peptides, are naturally
occurring peptides that can combat infections through their direct microbicidal properties …

The dual role of antimicrobial peptides in autoimmunity

W Liang, J Diana - Frontiers in immunology, 2020 - frontiersin.org
Autoimmune diseases (AiDs) are characterized by the destruction of host tissues by the host
immune system. The etiology of AiDs is complex, with the implication of multiple genetic …

[HTML][HTML] Intra-and extracellular degradation of neutrophil extracellular traps by macrophages and dendritic cells

B Lazzaretto, B Fadeel - The Journal of Immunology, 2019 - journals.aai.org
Neutrophil extracellular traps (NETs) composed of nuclear DNA associated with histones
and granule proteins are involved in the extracellular killing of pathogens. Excessive NET …

Crosstalk between B cells and neutrophils in rheumatoid arthritis

U Karmakar, S Vermeren - Immunology, 2021 - Wiley Online Library
Rheumatoid arthritis (RA) is a chronic, systemic autoimmune disease without known cure
that primarily affects synovial joints. RA has a prevalence of approximately 1% of the …

Immunological investigation of a multiepitope peptide vaccine candidate based on main proteins of SARS-CoV-2 pathogen

N Khairkhah, A Bolhassani, E Agi, A Namvar, A Nikyar - Plos one, 2022 - journals.plos.org
Multiepitope vaccines could induce multiantigenic immunity against large complex
pathogens with different strain variants. Herein, the in silico, in vitro and in vivo studies were …

Upregulating human cathelicidin antimicrobial peptide LL-37 expression may prevent severe COVID-19 inflammatory responses and reduce microthrombosis

KM Aloul, JE Nielsen, EB Defensor, JS Lin… - Frontiers in …, 2022 - frontiersin.org
COVID-19 is characterized by hyperactivation by inflammatory cytokines and recruitment of
macrophages, neutrophils, and other immune cells, all hallmarks of a strong inflammatory …

Antimicrobial peptide-tether dressing able to enhance wound healing by tissue contact

A Rai, R Ferrao, D Marta, A Vilaca, M Lino… - … Applied Materials & …, 2022 - ACS Publications
No effective therapeutic dressings are currently available in the market that can prevent
bacterial infection and simultaneously promote skin regeneration in diabetic patients. The …

TLR2 Activation by Porphyromonas gingivalis Requires Both PPAD Activity and Fimbriae

A Wielento, GP Bereta, KB Łagosz-Ćwik… - Frontiers in …, 2022 - frontiersin.org
Porphyromonas gingivalis, a keystone oral pathogen implicated in development and
progression of periodontitis, may also contribute to the pathogenicity of diseases such as …

Citrullination and the protein code: crosstalk between post-translational modifications in cancer

K Harada, SM Carr, A Shrestha… - … Transactions of the …, 2023 - royalsocietypublishing.org
Post-translational modifications (PTMs) of proteins are central to epigenetic regulation and
cellular signalling, playing an important role in the pathogenesis and progression of …

Citrullination alters the antiviral and immunomodulatory activities of the human cathelicidin LL-37 during rhinovirus infection

V Casanova, FH Sousa, P Shakamuri… - Frontiers in …, 2020 - frontiersin.org
Human rhinoviruses (HRV) are the most common cause of viral respiratory tract infections.
While normally mild and self-limiting in healthy adults, HRV infections are associated with …