[HTML][HTML] Comprehensive structural and molecular comparison of spike proteins of SARS-CoV-2, SARS-CoV and MERS-CoV, and their interactions with ACE2

MM Hatmal, W Alshaer, MAI Al-Hatamleh, M Hatmal… - Cells, 2020 - mdpi.com
The severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) has recently emerged
in China and caused a disease called coronavirus disease 2019 (COVID-19). The virus …

The study and application of biomolecules in deep eutectic solvents

JA Kist, H Zhao, KR Mitchell-Koch… - Journal of Materials …, 2021 - pubs.rsc.org
Biomolecules have been thoroughly investigated in a multitude of solvents historically in
order to accentuate or modulate their superlative properties in an array of applications. Ionic …

Enzyme hydration determines resistance in organic cosolvents

H Cui, L Zhang, L Eltoukhy, Q Jiang, SK Korkunç… - ACS …, 2020 - ACS Publications
Biocatalysis in organic solvents (OSs) has found various important applications, particularly
in organic synthesis and for the production of pharmaceuticals, flavors, and fragrances …

Computer-aided engineering of lipases solvent tolerance enhanced their applications in sugar esters synthesis: State of the art

Y Qi, M Chen, T Jin, W Chong, Z Zhang, B Nian… - Trends in Food Science & …, 2024 - Elsevier
Abstract Background Sugar esters (SEs) are non-ionic amphiphilic surfactants that possess
excellent emulsifying properties, and consequently have potential applications in the food …

What do we learn from enzyme behaviors in organic solvents?–Structural functionalization of ionic liquids for enzyme activation and stabilization

H Zhao - Biotechnology Advances, 2020 - Elsevier
Enzyme activity in nonaqueous media (eg conventional organic solvents) is typically lower
than in water by several orders of magnitude. There is a rising interest of developing new …

Utilizing machine learning to greatly expand the range and accuracy of bottom-up coarse-grained models through virtual particles

PG Sahrmann, TD Loose… - Journal of Chemical …, 2023 - ACS Publications
Coarse-grained (CG) models parametrized using atomistic reference data, ie,“bottom up”
CG models, have proven useful in the study of biomolecules and other soft matter. However …

How to engineer organic solvent resistant enzymes: Insights from combined molecular dynamics and directed evolution study

H Cui, THJ Stadtmüller, Q Jiang, KE Jaeger… - …, 2020 - Wiley Online Library
Expanding synthetic capabilities to routinely employ enzymes in organic solvents (OSs) is a
dream for protein engineers and synthetic chemists. Despite significant advances in the field …

Investigation of the enhancement mechanism of ethanol addition on the gel performance of heat-induced surimi

Z Xiong, X Wang, M Li, T Shi, W Jin, J Li, L Yuan… - Journal of Food …, 2023 - Elsevier
This study investigated the mechanism of ethanol enhancing the gel properties of heat-
induced silver carp (Hypophthalmichthys molitrix) surimi gels. The presence of ethanol …

Decreased water mobility contributes to increased α‐synuclein aggregation

AD Stephens, J Kölbel, R Moons… - Angewandte Chemie …, 2023 - Wiley Online Library
The solvation shell is essential for the folding and function of proteins, but how it contributes
to protein misfolding and aggregation has still to be elucidated. We show that the mobility of …

How Does Surface Charge Engineering of Bacillus subtilis Lipase A Improve Ionic Liquid Resistance? Lessons Learned from Molecular Dynamics Simulations

S Pramanik, H Cui, GV Dhoke, CB Yildiz… - ACS Sustainable …, 2022 - ACS Publications
Biocatalysis in ionic liquids (ILs) gained substantial interest due to solvent properties of the
ILs, such as near-zero vapor pressure, high thermal stability, and wide tunability. Enzymes …