CRISPR–cas9: A history of its discovery and ethical considerations of its use in genome editing

I Gostimskaya - Biochemistry (Moscow), 2022 - Springer
The development of a method for genome editing based on CRISPR–Cas9 technology was
awarded The Nobel Prize in Chemistry in 2020, less than a decade after the discovery of all …

Nanobiohybrids: Materials approaches for bioaugmentation

Z Guo, JJ Richardson, B Kong, K Liang - Science Advances, 2020 - science.org
Nanobiohybrids, synthesized by integrating functional nanomaterials with living systems,
have emerged as an exciting branch of research at the interface of materials engineering …

[图书][B] Science and moral imagination: A new ideal for values in science

MJ Brown - 2020 - books.google.com
The idea that science is or should be value-free, and that values are or should be formed
independently of science, has been under fire by philosophers of science for decades …

Posthumanism: A guide for the perplexed

P Mahon - 2017 - torrossa.com
Names: Mahon, Peter, 1971–author. Title: Posthumanism: a guide for the perplexed/by Peter
Mahon. Description: New York: Bloomsbury Academic, 2017.| Series: Guides for the …

Hereditary nephrogenic diabetes insipidus: pathophysiology and possible treatment. An update

S Milano, M Carmosino, A Gerbino, M Svelto… - International journal of …, 2017 - mdpi.com
Under physiological conditions, excessive loss of water through the urine is prevented by
the release of the antidiuretic hormone arginine-vasopressin (AVP) from the posterior …

Highly efficient and precise base editing in discarded human tripronuclear embryos

G Li, Y Liu, Y Zeng, J Li, L Wang, G Yang, D Chen… - Protein & …, 2017 - academic.oup.com
CRISPR/Cas9 is a powerful tool for genome editing (Komor et al., 2017). Recently, it has
been employed in several attempts to edit the human embryos (Liang et al., 2015; Kang et …

Development and application of CRISPR/Cas9 technologies in genomic editing

C Zhang, R Quan, J Wang - Human molecular genetics, 2018 - academic.oup.com
Genomic editing to correct disease-causing mutations is a promising approach for the
treatment of human diseases. As a simple and programmable nuclease-based genomic …

Next-generation CRISPR technology for genome, epigenome and mitochondrial editing

CH Lau, QL Liang, H Zhu - Transgenic Research, 2024 - Springer
The application of rapidly growing CRISPR toolboxes and methods has great potential to
transform biomedical research. Here, we provide a snapshot of up-to-date CRISPR …

The ethics of clinical applications of germline genome modification: a systematic review of reasons

I Van Dijke, L Bosch, AL Bredenoord… - Human …, 2018 - academic.oup.com
STUDY QUESTION What are the reasons for or against the future clinical application of
germline genome modification (GGM)? SUMMARY ANSWER A total of 169 reasons were …

Is CRISPR an ethical game changer?

M Schultz-Bergin - Journal of Agricultural and Environmental Ethics, 2018 - Springer
By many accounts, CRISPR gene-editing technology is revolutionizing biotechnology. It has
been hailed as a scientific game changer and is being adopted at a break-neck pace. This …