Antibody drug conjugate: the “biological missile” for targeted cancer therapy

Z Fu, S Li, S Han, C Shi, Y Zhang - Signal transduction and targeted …, 2022 - nature.com
Antibody–drug conjugate (ADC) is typically composed of a monoclonal antibody (mAbs)
covalently attached to a cytotoxic drug via a chemical linker. It combines both the …

Unlocking the potential of antibody–drug conjugates for cancer therapy

JZ Drago, S Modi, S Chandarlapaty - Nature Reviews Clinical …, 2021 - nature.com
Nine different antibody–drug conjugates (ADCs) are currently approved as cancer
treatments, with dozens more in preclinical and clinical development. The primary goal of …

An insight into FDA approved antibody-drug conjugates for cancer therapy

JTW Tong, PWR Harris, MA Brimble, I Kavianinia - Molecules, 2021 - mdpi.com
The large number of emerging antibody-drug conjugates (ADCs) for cancer therapy has
resulted in a significant market 'boom', garnering worldwide attention. Despite ADCs …

Site-selective modification strategies in antibody–drug conjugates

SJ Walsh, JD Bargh, FM Dannheim… - Chemical Society …, 2021 - pubs.rsc.org
Antibody–drug conjugates (ADCs) harness the highly specific targeting capabilities of an
antibody to deliver a cytotoxic payload to specific cell types. They have garnered …

Antibody–drug conjugates for cancer therapy

U Hafeez, S Parakh, HK Gan, AM Scott - Molecules, 2020 - mdpi.com
Antibody–drug conjugates (ADCs) are novel drugs that exploit the specificity of a
monoclonal antibody (mAb) to reach target antigens expressed on cancer cells for the …

Antibody–drug conjugates for cancer

CH Chau, PS Steeg, WD Figg - The Lancet, 2019 - thelancet.com
Antibody–drug conjugates (ADCs) are immunoconjugates comprised of a monoclonal
antibody tethered to a cytotoxic drug (known as the payload) via a chemical linker. The ADC …

Combining antibody-drug conjugates with immunotherapy in solid tumors: current landscape and future perspectives

E Nicolò, F Giugliano, L Ascione, P Tarantino… - Cancer Treatment …, 2022 - Elsevier
Antibody-drug conjugates (ADCs) and immunotherapy have prompted a revolution in the
treatment of cancer. However, only a limited fraction of patients obtained a long-term benefit; …

Antibody-drug conjugate-based therapeutics: state of the science

MJ Birrer, KN Moore, I Betella… - JNCI: Journal of the …, 2019 - academic.oup.com
Antibody-drug conjugates (ADCs) are complex engineered therapeutics consisting of
monoclonal antibodies, directed toward tumor-associated antigens, to which highly potent …

Antibody–drug conjugates—a tutorial review

S Baah, M Laws, KM Rahman - Molecules, 2021 - mdpi.com
Antibody–drug conjugates (ADCs) are a family of targeted therapeutic agents for the
treatment of cancer. ADC development is a rapidly expanding field of research, with over 80 …

Potential of antibody–drug conjugates (ADCs) for cancer therapy

HE Marei, C Cenciarelli, A Hasan - Cancer Cell International, 2022 - Springer
The primary purpose of ADCs is to increase the efficacy of anticancer medications by
minimizing systemic drug distribution and targeting specific cells. Antibody conjugates …