With the exception of a few monogenic forms, Alzheimer disease (AD) has a complex
aetiology that is likely to involve multiple susceptibility genes and environmental factors. The …

The epigenetic clock is defined by the DNA methylation (DNAm) level and has been
extensively applied to distinguish biological age from chronological age. Aging-related …

Background Growing evidence has demonstrated that DNA methylation (DNAm) plays an
important role in Alzheimer's disease (AD) and that DNAm differences can be detected in the …

To better understand DNA methylation in Alzheimer's disease (AD) from both mechanistic
and biomarker perspectives, we performed an epigenome-wide meta-analysis of blood DNA …

Epigenomic modifications of the brain-derived neurotrophic factor (BDNF) gene have been
postulated to underlie the pathogenesis of neurodevelopmental, psychiatric, and …

Alzheimer's disease (AD) is a progressive neurodegenerative disorder and represents the
leading cause of cognitive impairment and dementia in older individuals throughout the …

Methylation levels of the mitochondrial displacement loop (D-loop) region have been
reported to be altered in the brain and blood of Alzheimer's disease (AD) patients. Moreover …

Background Sex is increasingly recognized as a significant factor contributing to the
biological and clinical heterogeneity in AD. There is also growing evidence for the prominent …

Epigenetic mechanisms such as DNA methylation have been implicated in a number of
diseases including cancer, heart disease, autoimmune disorders, and neurodegenerative …

Alzheimer's disease (AD) is a common neurodegenerative disorder with a significant impact
on aging populations. DNA methylation (DNAm) alterations have been implicated in both the …