Epidemiology, pathogenesis, diagnosis and emerging treatment of nonalcoholic fatty liver disease

E Makri, A Goulas, SA Polyzos - Archives of medical research, 2021 - Elsevier
Nonalcoholic fatty liver disease (NAFLD) is the most common chronic liver disease, with an
estimated rising prevalence, in concert with the epidemics of obesity and type 2 diabetes …

Non-alcoholic fatty liver disease: an update with special focus on the role of gut microbiota

M Doulberis, G Kotronis, D Gialamprinou, J Kountouras… - Metabolism, 2017 - Elsevier
Non-alcoholic fatty liver disease (NAFLD) is a significant global health burden in children,
adolescents and adults with substantial rise in prevalence over the last decades …

Recent insights into the molecular pathophysiology of lipid droplet formation in hepatocytes

N Sahini, J Borlak - Progress in lipid research, 2014 - Elsevier
Triacyglycerols are a major energy reserve of the body and are normally stored in adipose
tissue as lipid droplets (LDs). The liver, however, stores energy as glycogen and digested …

Noninvasive liver fibrosis tests in patients with nonalcoholic fatty liver disease: an external validation cohort

SA Polyzos, A Slavakis… - Hormone and …, 2019 - thieme-connect.com
The main aim of this study was the comparative evaluation of nonalcoholic fatty liver disease
(NAFLD) fibrosis score (NFS), fibrosis 4 index (FIB-4), AST-to-Platelet Ratio Index (APRI) …

Necessity for timely noninvasive diagnosis of nonalcoholic fatty liver disease

SA Polyzos, CS Mantzoros - Metabolism, 2014 - Elsevier
Nonalcoholic fatty liver disease (NAFLD) is a major, global, public health problem; it is the
commonest hepatic disorder in Western countries and possibly the leading cause of …

Noninvasive tests do not accurately differentiate nonalcoholic steatohepatitis from simple steatosis: a systematic review and meta-analysis

P Verhaegh, R Bavalia, B Winkens, A Masclee… - Clinical …, 2018 - Elsevier
Background & Aims Nonalcoholic fatty liver disease is a rapidly increasing health problem.
Liver biopsy analysis is the most sensitive test to differentiate between nonalcoholic …

Targeted analysis of three hormonal systems identifies molecules associated with the presence and severity of NAFLD

SA Polyzos, N Perakakis, C Boutari… - The Journal of …, 2020 - academic.oup.com
Aims To investigate circulating levels and liver gene expression of 3 hormonal pathways
associated with obesity, insulin resistance, and inflammation to identify leads towards …

EFFECT OF HELICOBACTER PYLORI ERADICATION ON HEPATIC STEATOSIS, NAFLD FIBROSIS SCORE AND HSENSI IN PATIENTS WITH …

SA Polyzos, P Nikolopoulos, A Stogianni… - Arquivos de …, 2014 - SciELO Brasil
Context Limited clinical data suggest Helicobacter pylori (Hp) infection may contribute to
nonalcoholic fatty liver disease (NAFLD) pathogenesis. Objectives The effect of Hp …

Vaspin, resistin, retinol-binding protein-4, interleukin-1α and interleukin-6 in patients with nonalcoholic fatty liver disease

SA Polyzos, J Kountouras, V Polymerou… - Annals of …, 2017 - medigraphic.com
Background and rational. Data on newer adipokines and interleukins in patients with
nonalcoholic fatty liver disease (NAFLD) are inconclusive. The primary aim of this study was …

Circulating sclerostin and Dickkopf-1 levels in patients with nonalcoholic fatty liver disease

SA Polyzos, AD Anastasilakis, J Kountouras… - Journal of bone and …, 2016 - Springer
There is increasing evidence for bone-liver interplay. The main aim of this study was to
determine serum sclerostin and Dickkopf (DKK)-1 levels in patients with nonalcoholic fatty …