Amyloid beta: structure, biology and structure-based therapeutic development

G Chen, T Xu, Y Yan, Y Zhou, Y Jiang… - Acta pharmacologica …, 2017 - nature.com
Amyloid beta peptide (Aβ) is produced through the proteolytic processing of a
transmembrane protein, amyloid precursor protein (APP), by β-and γ-secretases. Aβ …

How can insulin resistance cause Alzheimer's disease?

JH Yoon, JH Hwang, SU Son, J Choi, SW You… - International Journal of …, 2023 - mdpi.com
Alzheimer's disease (AD) is a neurodegenerative disorder associated with cognitive decline.
Despite worldwide efforts to find a cure, no proper treatment has been developed yet, and …

Triaging between post-translational modification of cell cycle regulators and their therapeutics in neurodegenerative diseases

N Rani, M Sahu, RK Ambasta, P Kumar - Ageing Research Reviews, 2024 - Elsevier
Neurodegenerative diseases, such as Alzheimer's disease, Parkinson's disease, and
Huntington's disease, present challenges in healthcare because of their complicated …

Role of cell cycle re-entry in neurons: a common apoptotic mechanism of neuronal cell death

J Folch, F Junyent, E Verdaguer, C Auladell… - Neurotoxicity …, 2012 - Springer
Currently, there is no effective treatment for neurodegenerative disorders such as
Alzheimer's disease and Parkinson's disease. Thus, a major focus of neuroscience research …

Post-translational and post-transcriptional modifications of pregnane X receptor (PXR) in regulation of the cytochrome P450 superfamily

T Smutny, S Mani, P Pavek - Current drug metabolism, 2013 - ingentaconnect.com
Pregnane X receptor (PXR) is a member of the nuclear receptor (NR) superfamily of ligand-
activated transcription factors and is activated by a huge variety of endobiotics and …

Neuronal responses to physiological stress

K Kagias, C Nehammer, R Pocock - Frontiers in genetics, 2012 - frontiersin.org
Physiological stress can be defined as any external or internal condition that challenges the
homeostasis of a cell or an organism. It can be divided into three different aspects …

Suppressing Cdk5 Activity by Luteolin Inhibits MPP+-Induced Apoptotic of Neuroblastoma through Erk/Drp1 and Fak/Akt/GSK3β Pathways

R Reudhabibadh, T Binlateh, P Chonpathompikunlert… - Molecules, 2021 - mdpi.com
Parkinson's disease (PD) is characterized by the progressive degeneration of dopaminergic
neurons. The cause of PD is still unclear. Oxidative stress and mitochondrial dysfunction …

Protein kinases: master regulators of neuritogenesis and therapeutic targets for axon regeneration

SA Bennison, SM Blazejewski, TH Smith… - Cellular and Molecular …, 2020 - Springer
Proper neurite formation is essential for appropriate neuronal morphology to develop and
defects at this early foundational stage have serious implications for overall neuronal …

Structural Conversion of Serotonin into Amyloid-like Nanoassemblies Conceptualizes an Unexplored Neurotoxicity Risk

KP Prajapati, S Mittal, M Ansari, N Mishra, OP Mahato… - ACS …, 2024 - ACS Publications
The neuromodulator 5-hydroxytryptamine, known as serotonin, plays a key regulatory role in
the central nervous system and peripheral organs; however, several research revelations …

An Overview of Recent Advances in the Neuroprotective Potentials of Fisetin against Diverse Insults in Neurological Diseases and the Underlying Signaling Pathways

X Tang, P Deng, Y Jiang, L Zhang, Y He, H Yang - Biomedicines, 2023 - mdpi.com
The nervous system plays a leading role in the regulation of physiological functions and
activities in the body. However, a variety of diseases related to the nervous system have a …