Rethinking Immune Check Point Inhibitors Use in Liver Transplantation: Implications and Resistance
V Ortiz, E Loeuillard - Cellular and Molecular Gastroenterology and …, 2024 - Elsevier
Immune checkpoint inhibitors (ICI) have revolutionized cancer therapy including the two
most common liver tumors, hepatocellular carcinoma and cholangiocarcinoma, but their use …
most common liver tumors, hepatocellular carcinoma and cholangiocarcinoma, but their use …
CD154 blockade effectively controls antibody-mediated rejection in highly sensitized nonhuman primate kidney transplant recipients
Current desensitization and maintenance immunosuppression regimens for kidney
transplantation in sensitized individuals show limited ability to control the posttransplant …
transplantation in sensitized individuals show limited ability to control the posttransplant …
Prolonged xenokidney graft survival in sensitized NHP recipients by expression of multiple human transgenes in a triple knockout pig
Genetic modification of porcine donors, combined with optimized immunosuppression, has
been shown to improve outcomes of experimental xenotransplant. However, little is known …
been shown to improve outcomes of experimental xenotransplant. However, little is known …
Early allogeneic immune modulation after establishment of donor hematopoietic cell-induced mixed chimerism in a nonhuman primate kidney transplant model
CJ Little, SC Kim, JH Fechner, J Post… - Frontiers in …, 2024 - frontiersin.org
Background Mixed lymphohematopoietic chimerism is a proven strategy for achieving
operational transplant tolerance, though the underlying immunologic mechanisms are …
operational transplant tolerance, though the underlying immunologic mechanisms are …
Belatacept and carfilzomib-based treatment for antibody-mediated rejection in a sensitized nonhuman primate kidney transplantation model
Introduction One-third of HLA-incompatible kidney transplant recipients experience antibody
mediated rejection (AMR) with limited treatment options. This study describes a novel …
mediated rejection (AMR) with limited treatment options. This study describes a novel …
[HTML][HTML] Translation of therapeutic strategies to modulate B cell reponses from non-human primate models to human kidney transplantation
S Knechtle, J Kwun, S Song, A Jackson… - Frontiers in …, 2023 - frontiersin.org
Using novel drugs targeting lymphocyte costimulation, cytokines, antibody, complement, and
plasma cells, we have developed strategies in a non-human primate model to modulate the …
plasma cells, we have developed strategies in a non-human primate model to modulate the …
Perturbing Proteostasis to Deplete Plasma Cells
AP Rossi - 2023 - search.proquest.com
Anti-human leukocyte antigen antibodies (aHLA Ab) can form during a humoral immune
response to non-self HLA encountered during pregnancy, blood transfusion, or …
response to non-self HLA encountered during pregnancy, blood transfusion, or …
Desensitization and belatacept-based maintenance therapy in pregnancy-sensitized monkeys receiving a kidney transplant
Among sensitized patients awaiting a transplant, females are disproportionately
represented, partly because of pregnancy-induced sensitization. Using female NHPs …
represented, partly because of pregnancy-induced sensitization. Using female NHPs …