Hox proteins are well known for executing highly specific functions in vivo, but our
understanding of the molecular mechanisms underlying gene regulation by these …

Multipotent neural stem cells, capable of giving rise to both neurons and glia, line the
cerebral ventricles of all adult animals, including humans. In addition, distinct populations of …

Neurons in the cerebral cortex connect through descending pathways to hindbrain and
spinal cord to activate muscle and generate movement. Although components of this …

The ability to define cell types and how they change during organogenesis is central to our
understanding of animal development and human disease. Despite the crucial nature of this …

Compared with histone H3, acetylation of H4 tails has not been well studied, especially in
mammalian cells. Yet, H4K16 acetylation is of particular interest because of its ability to …

Motor neurons are functionally related, but represent a diverse collection of cells that show
strict preferences for specific axon pathways during embryonic development. In this article …

Background Human pluripotent stem cells (hPSCs) are being applied in regenerative
medicine and for the in vitro modeling of human intractable disorders. In particular, neural …

Abstract Transactivating DNA-binding protein-43 (TDP-43) deposits represent a typical
finding in almost all ALS patients, more than half of FTLD patients and patients with several …

In this review, we consider recent work using zebrafish to validate and study the functional
consequences of mutations of human genes implicated in a broad range of degenerative …

Human embryonic stem (hES) cells may generate all major somatic cell types, yet no
neuronal subtype has yet been specifically generated in useful purity from hES culture. We …