Antibiotic perturbations to the gut microbiome

SRS Fishbein, B Mahmud, G Dantas - Nature Reviews Microbiology, 2023 - nature.com
Antibiotic-mediated perturbation of the gut microbiome is associated with numerous
infectious and autoimmune diseases of the gastrointestinal tract. Yet, as the gut microbiome …

The physiology and genetics of bacterial responses to antibiotic combinations

R Roemhild, T Bollenbach, DI Andersson - Nature Reviews …, 2022 - nature.com
Several promising strategies based on combining or cycling different antibiotics have been
proposed to increase efficacy and counteract resistance evolution, but we still lack a deep …

Establishment and characterization of stable, diverse, fecal-derived in vitro microbial communities that model the intestinal microbiota

A Aranda-Díaz, KM Ng, T Thomsen, I Real-Ramírez… - Cell host & …, 2022 - cell.com
Efforts to probe the role of the gut microbiota in disease would benefit from a system in which
patient-derived bacterial communities can be studied at scale. We addressed this by …

A symbiotic physical niche in Drosophila melanogaster regulates stable association of a multi-species gut microbiota

R Dodge, EW Jones, H Zhu, B Obadia… - Nature …, 2023 - nature.com
The gut is continuously invaded by diverse bacteria from the diet and the environment, yet
microbiome composition is relatively stable over time for host species ranging from …

Towards a mechanistic understanding of reciprocal drug–microbiome interactions

M Zimmermann, KR Patil, A Typas… - Molecular systems …, 2021 - embopress.org
Broad‐spectrum antibiotics target multiple gram‐positive and gram‐negative bacteria, and
can collaterally damage the gut microbiota. Yet, our knowledge of the extent of damage, the …

Antibiotic resistance in bacterial communities

M Denk-Lobnig, KB Wood - Current opinion in microbiology, 2023 - Elsevier
Bacteria are single-celled organisms, but the survival of microbial communities relies on
complex dynamics at the molecular, cellular, and ecosystem scales. Antibiotic resistance, in …

Inter-species interactions alter antibiotic efficacy in bacterial communities

MJ Bottery, JL Matthews, AJ Wood… - The ISME …, 2022 - academic.oup.com
The efficacy of antibiotic treatments targeting polymicrobial communities is not well predicted
by conventional in vitro susceptibility testing based on determining minimum inhibitory …

Modulating the evolutionary trajectory of tolerance using antibiotics with different metabolic dependencies

EJ Zheng, IW Andrews, AT Grote, AL Manson… - Nature …, 2022 - nature.com
Antibiotic tolerance, or the ability of bacteria to survive antibiotic treatment in the absence of
genetic resistance, has been linked to chronic and recurrent infections. Tolerant cells are …

Highly oxidized oxide surface toward optimum oxygen evolution reaction by termination engineering

X Li, L Ge, Y Du, H Huang, Y Ha, Z Fu, Y Lu, W Yang… - ACS …, 2023 - ACS Publications
The oxygen evolution reaction (OER) is a critical step for sustainable fuel production through
electrochemistry process. Maximizing active sites of nanocatalyst with enhanced intrinsic …

Competition for fluctuating resources reproduces statistics of species abundance over time across wide-ranging microbiotas

PY Ho, BH Good, KC Huang - Elife, 2022 - elifesciences.org
Across diverse microbiotas, species abundances vary in time with distinctive statistical
behaviors that appear to generalize across hosts, but the origins and implications of these …