Abstract Purpose of Review The goal of this review is to summarize recent advances in
modeling of bone fracture using fracture mechanics–based approaches at multiple length …

Hard tissues (eg, bone, enamel, dentin) in vertebrates perform various and different
functions, from sustaining the body to haematopoiesis. Such complex and hierarchal tissue …

Bone features a remarkable combination of toughness and strength which originates from its
complex hierarchical structure and motivates its investigation on multiple length scales …

Previous experimental and computational studies have indicated that removing bound water
in bone matrix makes bone stiffer, stronger, but more brittle at different length scales …

In this study, we propose a 3D non-linear finite element (FE) unit-cell model to investigate
the post-yield behavior of mineralized collagen fibril arrays (FAY). We then compare the …

Osteogenesis imperfecta (OI), a brittle bone disease, is known to result in severe bone
fragility. However, its ultrastructural origins are still poorly understood. In this study, we …

Inspired by design motifs driving the balanced combination of rigidity, strength, and
toughness in biological materials, this paper presents 3D computational modeling and …

At the tissue-scale and above, there are now well-established structure-property
relationships that provide good approximations of the biomechanical performance of bone …

It is well documented that fragility fractures represent an enormous health, economic and
psycho-social burden, leading to severe pain, loss of mobility, and even death. While clinical …

Abstract The Surgeon General estimates that by 2020, half of all Americans could have
weak bones due to bone loss. Osteoporosis causes more than 1.5 million fractures every …