The role of the indoles in microbiota-gut-brain axis and potential therapeutic targets: A focus on human neurological and neuropsychiatric diseases

Y Zhou, Y Chen, H He, M Peng, M Zeng, H Sun - Neuropharmacology, 2023 - Elsevier
At present, a large number of relevant studies have suggested that the changes in gut
microbiota are related to the course of nervous system diseases, and the microbiota-gut …

The therapeutic potential of dietary intervention: based on the mechanism of a tryptophan derivative-indole propionic acid on metabolic disorders

B Niu, T Pan, Y Xiao, H Wang, J Zhu… - Critical Reviews in …, 2023 - Taylor & Francis
Tryptophan (TRP) contributes to individual immune homeostasis and good condition via
three complex metabolism pathways (5-hydroxytryptamine (5-HT), kynurenine (KP), and gut …

Hypoxanthine is a metabolic biomarker for inducing GSDME-dependent pyroptosis of endothelial cells during ischemic stroke

J Ye, X Bi, S Deng, X Wang, Z Liu, Q Suo, J Wu… - …, 2024 - pmc.ncbi.nlm.nih.gov
Rationale: Stroke induces metabolic changes in the body, and metabolites have become
potential biomarkers for stroke. However, the specific metabolites involved in stroke and the …

Plant protein but not animal protein consumption is associated with frailty through plasma metabolites

T Tanaka, JK Das, Y Jin, Q Tian, R Moaddel, AZ Moore… - Nutrients, 2023 - mdpi.com
There is evidence that the association of protein intake and frailty may depend on the source
of dietary protein. The mechanism underlying this association is not clear. In this study, we …

Gut microbiota-associated metabolites and risk of ischemic stroke in REGARDS

Z Ament, A Patki, VM Bhave… - Journal of Cerebral …, 2023 - journals.sagepub.com
Several metabolite markers are independently associated with incident ischemic stroke.
However, prior studies have not accounted for intercorrelated metabolite networks. We used …

Association of circulating metabolites with racial disparities in hypertension and stroke in the REGARDS study

N Kijpaisalratana, Z Ament, A Patki, VM Bhave… - Neurology, 2023 - AAN Enterprises
Background and Objectives In the United States, the risk of stroke is greater among Black
compared with that among White individuals. However, the reasons for the difference in …

[HTML][HTML] The Mediterranean-DASH Intervention for Neurodegenerative Delay (MIND) Diet and Metabolites in Chronic Kidney Disease

CA Couch, Z Ament, A Patki, N Kijpaisalratana… - Nutrients, 2024 - mdpi.com
The Mediterranean-DASH Intervention for Neurodegenerative Delay (MIND) is a hybrid of
the Mediterranean and DASH (Dietary Approaches to Stop Hypertension) diets, and its …

Acetylglutamine differentially associated with first-time versus recurrent stroke

N Kijpaisalratana, Z Ament, A Patki, VM Bhave… - Translational Stroke …, 2024 - Springer
Approximately one-quarter of strokes occur in individuals with prior stroke. Despite the
advancement in secondary stroke prevention, the long-term risk of recurrent stroke has …

Associations Between Ultra-Processed Food Consumption and Adverse Brain Health Outcomes

VM Bhave, CR Oladele, Z Ament, N Kijpaisalratana… - Neurology, 2024 - AAN Enterprises
Background and Objectives Ultra-processed foods (UPFs) are linked to cardiometabolic
diseases and neurologic outcomes, such as cognitive decline and stroke. However, it is …

[HTML][HTML] Systematic Insights into the Relationship between the Microbiota–Gut–Brain Axis and Stroke with the Focus on Tryptophan Metabolism

X Shen, X Mu - Metabolites, 2024 - mdpi.com
Stroke, as a serious cerebral vascular disease with high incidence and high rates of
disability and mortality, has limited therapeutic options due to the narrow time window …