As dietary guidance for populations shifts from preventing deficiency disorders to chronic
disease risk reduction, the biology supporting such guidance becomes more complex due to …

Vitamin B micronutrients are essential regulators of one carbon metabolism that ensures
human health. Vitamin B9, or folate, lies at the heart of the folate cycle and converges with …

Background Neural tube defects are common birth defects resulting in severe morbidity and
mortality; they can largely be prevented with periconceptional maternal intake of folic acid …

Folic acid (FA) is well known to prevent neural tube defects (NTDs), but we do not know why
many human NTD cases still remain refractory to FA supplementation. Here, we investigate …

Neural tube defects (NTDs) consist of severe structural malformations of the brain and spinal
cord and are the second most common structural birth defect in humans, accounting for …

Existing evidence supported that congenital heart defect (CHD) was associated with a
combination of environmental and genetic factors. Based on this, this study aimed at …

The preconception period is a unique and opportunistic time in a woman's life when she is
motivated to adopt healthy behaviors that will benefit her and her child, making this time …

Neural tube closure is a fundamental process during vertebrate embryogenesis, which leads
to the formation of the central nervous system. Defective neural tube closure leads to neural …

Background Double-fortified salt (DFS; iron, iodine) improved iron status in randomized trials
and was incorporated into India's social safety net programs, suggesting opportunities to …

Non-syndromic cleft lip with or without palate (NSCL/P) is a prevalent birth defect that affects
1/500–1/1400 live births globally. The genetic basis of NSCL/P is intricate and involves both …