Efficacy of Synriam™, a new antimalarial combination of OZ277 and piperaquine, against different developmental stages of Schistosoma mansoni

SF Mossallam, EI Amer, MH El-Faham - Acta Tropica, 2015 - Elsevier
Control of schistosomiasis relies on a single drug, praziquantel (PZQ). Given the rising
concerns about the potential emergence of PZQ-resistant strains, it has now become …

Double impact: natural molluscicide for schistosomiasis vector control also impedes development of Schistosoma mansoni cercariae into adult parasites

RC Augusto, G Tetreau, P Chan… - PLoS neglected …, 2017 - journals.plos.org
Background Schistosomiasis has been reported in 78 endemic countries and affects 240
million people worldwide. The digenetic parasite Schistosoma mansoni needs fresh water to …

[HTML][HTML] In vitro praziquantel test capable of detecting reduced in vivo efficacy in Schistosoma mansoni human infections

PHL Lamberton, SC Hogan… - The American journal …, 2010 - ncbi.nlm.nih.gov
Although great reductions in human schistosomiasis have been observed after praziquantel
(PZQ) mass drug administration (MDA), some individuals remain infected after multiple …

[HTML][HTML] Ultrastructural alterations in Schistosoma mansoni juvenile and adult male worms after in vitro incubation with primaquine

ROA Kamel, FEZA Bayaumy - Memórias do Instituto Oswaldo Cruz, 2017 - SciELO Brasil
BACKGROUND Praziquantel has been cited as the only drug for treating schistosomiasis.
However, concerns over drug resistance have encouraged the search for novel drug leads …

Superb bio-effectiveness of Cobalt (II) phthalocyanine and Ag NPs adorned Sm-doped ZnO nanorods/cuttlefish bone to annihilate Trichinella spiralis muscle larvae …

FEA Bayaumy, SA Rizk, AS Darwish - Parasitology International, 2024 - Elsevier
Herein, innovative biocides are designed for the treatment of Trichinella spiralis muscle
larvae (ML) and adult worms. Samarium-doped ZnO nanorods (Sm-doped ZnO) are …

Ultrastructural alterations in adult Schistosoma mansoni, harbored in non-antihelminthic treated and low-inflammatory mice by transmission electron microscopy (TEM …

AML Xavier, D Tavares, EV Guimarães… - Acta tropica, 2014 - Elsevier
This original study suggests that alterations observed on tegumental structure and egg
quality of adult Schistosoma mansoni harvested from TS mice are due to their high immune …

Assessment of the potential therapeutic effects of omeprazole in Schistosoma mansoni infected mice

AR Ellakany, DI Elgendy, HA Alshenawy… - Parasitology …, 2019 - Springer
Schistosomiasis is a neglected chronic parasitic disease with a significant lasting morbidity.
Currently, praziquantel (PZQ) is the most efficient drug for schistosomiasis worldwide …

[PDF][PDF] Nanopharmaceutical approach of epiisopiloturine alkaloid carried in liposome system: preparation and in vitro schistosomicidal activity.

MA Guimarães, YD Campelo, LM Véras… - Nanoscience and …, 2013 - academia.edu
Schistosomiasis is a neglected tropical disease caused by blood flukes of the genus
Schistosoma. This disease control has been widely made by praziquantel-reference drug …

Imaging trematode and nematode parasites

EJ Pearce, JB Lok - Parasite Immunology, 2013 - Wiley Online Library
Recent advances in molecular genetics and in imaging mean that it is now increasingly
feasible to image biological processes within helminth parasites and to visualize interactions …

[HTML][HTML] High IL-4 production related to granuloma development in high-tolerogenic mice infected with Schistosoma mansoni.

D Tavares, AML Xavier, AC Da Silva - frontiersin.org
Results: TS infected mice showed hepatosplenomegaly more intense (Figure 1A) and larger
size of hepatic granulomas (Figure 1B) than TR strain. When infected, both strains produced …