Folding of the cerebral cortex is a fundamental milestone of mammalian brain evolution and
is associated with dramatic increases in size and complexity. New animal models, genetic …

The ability to model human brain development in vitro represents an important step in our
study of developmental processes and neurological disorders. Protocols that utilize human …

Human accelerated regions (HARs) are the fastest-evolving regions of the human genome,
and many are hypothesized to function as regulatory elements that drive human-specific …

Evolutionary expansion of the human neocortex reflects increased amplification of basal
progenitors in the subventricular zone, producing more neurons during fetal corticogenesis …

Human neocortex expansion likely contributed to the remarkable cognitive abilities of
humans. This expansion is thought to primarily reflect differences in proliferation versus …

One of the most prominent features of the human brain is the fabulous size of the cerebral
cortex and its intricate folding. Cortical folding takes place during embryonic development …

Larger brains tend to have more folded cortices, but what makes the cortex fold has
remained unknown. We show that the degree of cortical folding scales uniformly across …

The human cerebral cortex depends for its normal development and size on a precisely
controlled balance between self-renewal and differentiation of diverse neural progenitor …

Neocortical expansion, thought to underlie the cognitive traits unique to humans, is
accompanied by cortical folding. This folding starts around gestational week (GW) 20, but …

Understanding the molecular basis that underlies the expansion of the neocortex during
primate, and notably human, evolution requires the identification of genes that are …