In high-, middle-and low-income countries, the rising prevalence of obesity is the underlying
cause of numerous health complications and increased mortality. Being a complex and …

Current medication for anxiety disorders is suboptimal in terms of efficiency and tolerability,
highlighting the need for improved drug treatments. In this review an overview of drugs …

The psychoactive constituent in cannabis, Δ9-tetrahydrocannabinol (THC), was isolated in
the mid-1960s, but the cannabinoid receptors, CB1 and CB2, and the major endogenous …

Isolation and structure elucidation of most of the major cannabinoid constituents—including
Δ9-tetrahydrocannabinol (Δ9-THC), which is the principal psychoactive molecule in …

The ideal anti-obesity drug would produce sustained weight loss with minimal side effects.
The mechanisms that regulate energy balance have substantial built-in redundancy, overlap …

Introduction: The opioid epidemic has become an immense problem in North America, and
despite decades of research on the most effective means to treat opioid use disorder (OUD) …

Dopamine (DA) is a major catecholamine neurotransmitter in the mammalian brain that
controls neural circuits involved in the cognitive, emotional, and motor aspects of goal …

The endocannabinoid system (ECS), comprising two G protein-coupled receptors (the
cannabinoid receptors 1 and 2 [CB1 and CB2] for marijuana's psychoactive principle∆ 9 …

Changes in lipid metabolism are intimately related to cancer. Several classes of bioactive
lipids play roles in the regulation of signaling pathways involved in neoplastic transformation …

More than 76 million people world‐wide are estimated to have diagnosable alcohol use
disorders (AUDs)(alcohol abuse or dependence), making these disorders a major global …