Effects of machine perfusion strategies on different donor types in liver transplantation: a systematic review and meta-analysis

A Liang, W Cheng, P Cao, S Cai, L Zhang… - … Journal of Surgery, 2023 - journals.lww.com
Background: The increasing use of extended criteria donors (ECD) sets higher requirements
for graft preservation. Machine perfusion (MP) improves orthotopic liver transplantation …

Machine perfusion for extended criteria donor livers: what challenges remain?

J Widmer, J Eden, MF Carvalho, P Dutkowski… - Journal of Clinical …, 2022 - mdpi.com
Based on the renaissance of dynamic preservation techniques, extended criteria donor
(ECD) livers reclaimed a valuable eligibility in the transplantable organ pool. Being more …

Viability assessment and transplantation of fatty liver grafts using end‐ischemic normothermic machine perfusion

D Patrono, R De Carlis, A Gambella… - Liver …, 2023 - journals.lww.com
End‐ischemic viability testing by normothermic machine perfusion (NMP) represents an
effective strategy to recover liver grafts having initially been discarded for liver …

Mitochondrial injury during normothermic regional perfusion (NRP) and hypothermic oxygenated perfusion (HOPE) in a rodent model of DCD liver transplantation

R Panconesi, MF Carvalho, J Eden, M Fazi, F Ansari… - …, 2023 - thelancet.com
Background Normothermic regional perfusion (NRP) and hypothermic-oxygenated-
perfusion (HOPE), were both shown to improve outcomes after liver transplantation from …

Donation after circulatory death: Novel strategies to improve the liver transplant outcome

R De Carlis, P Muiesan, B Taner - Journal of Hepatology, 2023 - Elsevier
In many countries, donation after circulatory death (DCD) liver grafts are used to overcome
organ shortages; however, DCD grafts have been associated with an increased risk of …

US liver transplant outcomes after normothermic regional perfusion vs standard super rapid recovery

AL Brubaker, MT Sellers, PL Abt, KP Croome… - JAMA …, 2024 - jamanetwork.com
Importance Normothermic regional perfusion (NRP) is an emerging recovery modality for
transplantable allografts from controlled donation after circulatory death (cDCD) donors. In …

Liver transplantation with uncontrolled versus controlled DCD donors using normothermic regional perfusion and ex-situ machine perfusion

D Ghinolfi, D Patrono, R De Carlis… - Liver …, 2024 - journals.lww.com
In Italy, 20 minutes of continuous, flat-line electrocardiogram are required for death
declaration, which significantly increases the risks of donation after circulatory death (DCD) …

How to preserve steatotic liver grafts for transplantation

D Patrono, N De Stefano, E Vissio, AL Apostu… - Journal of Clinical …, 2023 - mdpi.com
Liver allograft steatosis is a significant risk factor for postoperative graft dysfunction and has
been associated with inferior patient and graft survival, particularly in the case of moderate …

Normothermic regional perfusion in controlled DCD liver procurement: Outcomes of the Swedish national implementation protocol

E Bluhme, M Gäbel, LM de la Maza, V Nilsén… - Liver …, 2024 - journals.lww.com
Liver transplantation (LTX) using donors after controlled circulatory death (cDCD) is
associated with poorer graft survival and increased incidence of nonanastomotic biliary …

Impact of hypothermic oxygenated machine perfusion on hepatocellular carcinoma recurrence after liver transplantation

F Rigo, N De Stefano, D Patrono, V De Donato… - Journal of Personalized …, 2023 - mdpi.com
Background: Machine perfusion may be able to mitigate ischemia-reperfusion injury (IRI),
which increases hepatocellular carcinoma (HCC) recurrence after liver transplantation (LT) …