Over the past two decades, the Notch signaling pathway has been investigated as a
therapeutic target for the treatment of cancers, and more recently in the context of immune …

Purpose of Review IL-6 is a pleiotropic, pro-inflammatory cytokine that plays an integral role
in the development of acute and chronic rejection after solid organ transplantation. This …

Interleukin-6 (IL-6) is a proinflammatory cytokine and key regulator of Treg: T effector cell
(Teff) balance. We hypothesized that IL-6 blockade with tocilizumab, a monoclonal antibody …

Abstract Background Tumour associated neutrophils (TANs) play a controversial role in
regulating immune surveillance and immune evasion in various malignancies. Here, we …

Conventional T (Tcon) cells are crucial in shaping the immune response, whether it is
protection against a pathogen, a cytotoxic attack on tumor cells, or an unwanted response to …

Abstract CD4+ CD25+ FoxP3+ regulatory T cells (Tregs) are exploited by mycobacteria to
subvert the protective host immune responses. The Treg expansion in the periphery requires …

Background: Transplantation is the treatment of choice for many patients with end-stage
organ disease. Despite advances in immunosuppression, long-term outcomes remain …

Background Notch intercellular communication instructs tissue-specific T-cell development
and function. In this study, we explored the roles of dendritic cell (DC)-expressed Notch …

A high-salt diet (HSD) in humans is linked to a number of complications, including
hypertension and cardiovascular events. Whether a HSD affects the immune response in …

Signaling through Notch receptors intrinsically regulates tumor cell development and
growth. Here, we studied the role of the Notch ligand Jagged2 on immune evasion in non …