Protein stability is a topic of major interest for the biotechnology, pharmaceutical and food
industries, in addition to being a daily consideration for academic researchers studying …

Abstract Knowledge of the three-dimensional structures of protein targets now emerging
from genomic data has the potential to accelerate drug discovery greatly. X-ray …

Protein crystallization constitutes a limiting step in structure determination by X-ray
diffraction. Even if single crystals are available, inadequate physical quality may seriously …

Crystallization remains a critical step in X-ray structure determination. Because it is not
generally possible to rationally predict crystallization conditions, commercial screens have …

Protein crystallization remains a key limiting step in the characterization of the atomic
structures of proteins and their complexes by X-ray diffraction methods. Current data indicate …

The highly diverse Numb-associated kinase (NAK) family has been linked to broad cellular
functions including receptor-mediated endocytosis, Notch pathway modulation, osteoblast …

X-ray crystallography is the most powerful method for determining the three-dimensional
structure of biological macromolecules. One of the major obstacles in the process is the …

Trans-sialidases (TS) are GPI-anchored surface enzymes expressed in specific
developmental stages of trypanosome parasites like Trypanosoma cruzi, the etiologic agent …

Strategies for growing protein crystals have for many years been essentially empirical, the
protein, once purified to a certain homogeneity, being mixed with a selection of …

Coupling of ubiquitin conjugation to ER degradation (CUE) domains are∼ 50 amino acid
monoubiquitin binding motifs found in proteins of trafficking and ubiquitination pathways …