Globally, too many people die prematurely from suicide and the physical comorbidities
associated with mental illness and mental distress. The purpose of this Review is to mobilise …

Background: Delayed cerebral ischemia (DCI) is a common and serious complication of
aneurysmal subarachnoid hemorrhage (aSAH). Though many clinical trials have looked at …

Since their first appearance in the context of schizophrenia and bipolar disorder in 2009,
polygenic risk scores (PRSs) have been described for a large number of common complex …

Polygenic scores (PGS) are commonly evaluated in terms of their predictive accuracy at the
population level by the proportion of phenotypic variance they explain. To be useful for …

Researchers aim to develop polygenic risk scores as a tool to prevent and more effectively
treat serious diseases, disorders and conditions such as breast cancer, type 2 diabetes …

Twin and family studies show a strong contribution of genetic factors to physical activity (PA)
assessed by either self-report or accelerometers. PA heritability is around 43% across the …

In recent years, genome-wide association studies (GWAS) have been instrumental in
unraveling the genetic architecture of complex diseases, including psoriasis. The application …

Advances in genomics have enabled the development of polygenic scores (PGS),
sometimes called polygenic risk scores, in the context of multifactorial diseases and …

Purpose The use of patient race in medicine is controversial for its potential either to
exacerbate or address health disparities. Polygenic risk scores (PRSs) have emerged as a …

Polygenic models have emerged as promising prediction tools for the prediction of complex
traits. Currently, the majority of polygenic models are developed in the context of predicting …