Enantioconvergent catalysis has expanded asymmetric synthesis to new methodologies
able to convert racemic compounds into a single enantiomer. This review covers recent …

The asymmetric alkylation of enolates is a particularly versatile method for the construction
of α-stereogenic carbonyl motifs, which are ubiquitous in synthetic chemistry. Over the past …

Optically active α-arylation carbonyl units are widely present in a wide variety of drugs,
bioactive natural products, and valuable pharmacologically active molecules. Catalytic …

Synthetic application of asymmetric catalysis relies on strategic alignment of bond
construction to creation of chirality of a target molecule. Remote desymmetrization offers …

Acyclic quaternary carbon stereocenters exist widely in natural products and bioactive
molecules, but their enantioselective construction remains a prominent challenge. In …

Chiral nitriles are valuable molecules in modern organic synthesis and drug discovery.
Selectively differentiating the two nitrile groups of widely available malononitrile derivatives …

A facile α-arylation of nitriles has been developed by simply introducing Tf2O and DABCO to
the mixture of nitriles and aryl sulfoxides. The transformation consists of two sequential …

The design of new ligands for cross-coupling is essential for developing new catalytic
reactions that access valuable products such as pharmaceuticals. In this report, we exploit …

A Pd‐catalyzed fluoroarylation of gem‐difluoroalkenes with aryl halides is reported. By
taking advantage of the in situ generated α‐CF3‐benzylsilver intermediates derived from the …

Abstract α‐(Hetero) aryl nitriles are important structural motifs for pharmaceutical design.
The known methods for direct synthesis of these compounds via coupling with (hetero) aryl …