Multiple sclerosis (MS) represents the most common acquired demyelinating disorder of the
central nervous system (CNS). Its pathogenesis, in parallel with the well-established role of …

The innate immune system protects the host from external pathogens and internal damage
in various ways. The cGAS-STING signaling pathway, comprised of cyclic GMP-AMP …

As a chronic autoinflammatory condition, ulcerative colitis is often managed via systemic
immunosuppressants. Here we show, in three mouse models of established ulcerative …

This study aimed to explore the role of a stimulator of interferon (IFN) gene (STING) agonist
in breast cancer (BCa) immunotherapy. Clinical samples were collected from 37 patients …

Cyclic dinucleotides (CDNs), originally discovered as bacterial second messengers, play
critical roles in bacterial signal transduction, cellular processes, biofilm formation, and …

Monocytes are innate immune cells that sense environmental changes and participate in the
immunoregulation of autoimmune, neurologic, cardiovascular, and metabolic diseases as …

Subunit vaccines employing designer antigens such as Computationally Optimized Broadly
Reactive Antigen (COBRA) hemagglutinin (HA) hold the potential to direct the immune …

Evidence has shown that DNA is a pathogen‐associated molecular pattern, posing a unique
challenge in the discrimination between endogenous and foreign DNA. This challenge is …

Type I interferons (IFNs-I) are inflammatory cytokines that play an essential role in the
pathogenesis of inflammation and autoimmune diseases. Signaling through nucleic acid …

The STING signaling pathway has gained attention over the last few years due to its ability to
incite antimicrobial and antitumoral immunity. Conversely, in mouse models of autoimmunity …