Microfluidic deformability cytometry: A review
Y Chen, K Guo, L Jiang, S Zhu, Z Ni, N Xiang - Talanta, 2023 - Elsevier
Cell deformability plays an important role in cellular processes and functions, including cell
growth and differentiation, as well as cell transfer and cell cycle. Measuring deformability at …
growth and differentiation, as well as cell transfer and cell cycle. Measuring deformability at …
A survey of physical methods for studying nuclear mechanics and mechanobiology
It is increasingly appreciated that the cell nucleus is not only a home for DNA but also a
complex material that resists physical deformations and dynamically responds to external …
complex material that resists physical deformations and dynamically responds to external …
Impedance‐enabled camera‐free intrinsic mechanical cytometry
Mechanical properties of single cells are important label‐free biomarkers normally
measured by expensive and complex imaging systems. To unlock this limit and allow …
measured by expensive and complex imaging systems. To unlock this limit and allow …
Single-cell stretching in viscoelastic fluids with electronically triggered imaging for cellular mechanical phenotyping
Cellular mechanical phenotypes in connection to physiological and pathological states of
cells have become a promising intrinsic biomarker for label-free cell analysis in various …
cells have become a promising intrinsic biomarker for label-free cell analysis in various …
Developments in label‐free microfluidic methods for single‐cell analysis and sorting
Advancements in microfluidic technologies have led to the development of many new tools
for both the characterization and sorting of single cells without the need for exogenous …
for both the characterization and sorting of single cells without the need for exogenous …
Biophysical phenotyping of single cells using a differential multiconstriction microfluidic device with self-aligned 3D electrodes
Precise measurement of mechanical and electrical properties of single cells can yield useful
information on the physiological and pathological state of cells. In this work, we develop a …
information on the physiological and pathological state of cells. In this work, we develop a …
A systematic study of size correlation and Young's modulus sensitivity for cellular mechanical phenotyping by microfluidic approaches
Cellular mechanical properties are a class of intrinsic biophysical markers for cell state and
health. Microfluidic mechanical phenotyping methods have emerged as promising tools to …
health. Microfluidic mechanical phenotyping methods have emerged as promising tools to …
High-throughput adjustable deformability cytometry utilizing elasto-inertial focusing and virtual fluidic channel
Z Zhou, C Ni, Z Zhu, Y Chen, Z Ni, N Xiang - Lab on a Chip, 2023 - pubs.rsc.org
Cell mechanical properties provide a label-free marker for indicating cell states and disease
processes. Although microfluidic deformability cytometry has demonstrated great potential …
processes. Although microfluidic deformability cytometry has demonstrated great potential …
Inertial Multi‐Force Deformability Cytometry for High‐Throughput, High‐Accuracy, and High‐Applicability Tumor Cell Mechanotyping
Y Chen, C Ni, L Jiang, Z Ni, N Xiang - Small, 2024 - Wiley Online Library
Previous on‐chip technologies for characterizing the cellular mechanical properties often
suffer from a low throughput and limited sensitivity. Herein, an inertial multi‐force …
suffer from a low throughput and limited sensitivity. Herein, an inertial multi‐force …
Mechanobiology in oncology: basic concepts and clinical prospects
The interplay between genetic transformations, biochemical communications, and physical
interactions is crucial in cancer progression. Metastasis, a leading cause of cancer-related …
interactions is crucial in cancer progression. Metastasis, a leading cause of cancer-related …