Simvastatin-Loaded Polymeric Nanoparticles: Targeting Inflammatory Macrophages for Local Adipose Tissue Browning in Obesity Treatment

N Mohaghegh, A Ahari, C Buttles, S Davani, H Hoang… - ACS …, 2024 - ACS Publications
Obesity is defined as chronic, low-grade inflammation within specific tissues. Given the
escalating prevalence of obesity among individuals of all ages, obesity has reached …

[PDF][PDF] Several statins increase body and liver fat accumulation in a model of metabolic syndrome

L Aguirre, E Hijona, MT Macarulla, A Gracia… - J Physiol …, 2013 - jpp.krakow.pl
Statins are a family of drugs used in hypercholesterolemia. The aim of this study was to
analyze the effect of statins on body and liver fat accumulation in obese Zucker rats. Seventy …

Structural effects of simvastatin on rat liver tissue: Fourier transform infrared and Raman microspectroscopic studies

S Garip, SH Bayari, M Severcan… - Journal of …, 2016 - spiedigitallibrary.org
Simvastatin is one of the most frequently prescribed statins because of its efficacy in the
treatment of hypercholesterolemia, reducing cardiovascular risk and related mortality …

Delayed reproductive development in pubertal male rats exposed to the hypolipemiant agent rosuvastatin since prepuberty

GAA Leite, J de Lima Rosa, M Sanabria… - Reproductive …, 2014 - Elsevier
Dyslipidemias are frequently found in children due to obesity, bad eating habits and the lack
of physical exercises. Rosuvastatin acts as an HMG-CoA reductase inhibitor, decreasing …

Investigating the pathogenesis and risk of Type 2 diabetes: clinical applications of metabolomics

TW Ng, AA Khan, PJ Meikle - Clinical Lipidology, 2012 - Taylor & Francis
Many countries are facing an obesity epidemic and an associated increase in Type 2
diabetes (T2D). T2D and its complications are major causes of morbidity and mortality …

Global correlation analysis for microRNA and gene expression profiles in human obesity

J Li, C Zhou, J Li, Z Su, H Sang, E Jia, D Si - Pathology-Research and …, 2015 - Elsevier
Obesity is an increasing health problem associated with major adverse consequences for
human health. MicroRNAs (miRNAs), small endogenous non-coding RNAs, regulate the …

Effect of Raphanus sativus (Radish) Leaf Extract and High Doses of Atorvastatin on Body Weight, Liver Weight and Liver/Body Weight Ratio

O Anwar, M Iqbal, AM Khan, S Tariq… - Annals of Punjab …, 2020 - apmcfmu.com
Background: Obesity is a global health problem. The chances of metabolic disorders such
as type 2 diabetes, systemic hypertension, cardiovascular disease, dyslipidemia, and …

姜黄素对洛伐他汀在非酒精性脂肪肝大鼠体内药代动力学行为的影响

谢媛, 王洪, 冯冬, 郝海平, 王广基 - 中国药科大学学报, 2013 - jcpu.cpu.edu.cn
考察姜黄素对非酒精性脂肪肝的治疗作用及洛伐他汀在正常, 非酒精性脂肪肝模型大鼠及姜黄素
治疗大鼠体内的药代动力学行为变化. 采用高脂饮食饲养大鼠造成非酒精性脂肪肝病理模型 …

Structural effects of simvastatin on rat liver tissue: Fourier transform infrared and Raman microspectroscopic studies (vol 21, 025008, 2016)

Ş Garip, SH Bayari, M Severcan, S Abbas, IK Lednev… - 2016 - openaccess.altinbas.edu.tr
Simvastatin is one of the most frequently prescribed statins because of its efficacy in the
treatment of hypercholesterolemia, reducing cardiovascular risk and related mortality …