From the clinical standpoint, systemic sclerosis (SSc) is characterized by skin and internal
organ fibrosis, diffuse fibroproliferative vascular modifications, and autoimmunity. Clinical …

Inflammatory dermatosis is characterized by persistent inflammatory infiltration and hard
repair of diseased skin. As a member of the human innate immune cells, macrophages …

Janus kinase (JAK) inhibitors (also termed Jakinibs) constitute a family of small drugs that
target various isoforms of JAKs (JAK1, JAK2, JAK3 and/or tyrosine kinase 2 (Tyk2)). They …

Through their potential pro-fibrotic and pro-inflammatory properties, macrophages are at the
cross-road of key SSc pathogenic processes and associated manifestations. Investigative …

Systemic sclerosis (SSc) is a rare multisystem autoimmune disease, characterized by
fibrosis, vasculopathy, and autoimmunity. Recent advances have highlighted the significant …

Systemic sclerosis (SSc) is a destructive connective tissue disease characterized by
dysregulation of the immune system and fibrosis in the skin and internal organs. The …

Diffuse cutaneous systemic sclerosis (dcSSc) is associated with high mortality resulting from
early internal-organ involvement. Clinicians therefore tend to focus on early diagnosis and …

Ceramides are the predominant lipids in the stratum corneum (SC) and are crucial
components for normal skin barrier function. Although the composition of various ceramide …

Dysbiosis has been identified in many dermatological conditions (eg, psoriasis, atopic
dermatitis, systemic lupus erythematosus). One of the ways by which the microbiota affect …

Idiopathic inflammatory myopathies (IIM), even though sharing common clinical
manifestations, are characterized by diversified molecular pathogenetic mechanisms which …