Synovial inflammation in osteoarthritis progression

E Sanchez-Lopez, R Coras, A Torres… - Nature Reviews …, 2022 - nature.com
Osteoarthritis (OA) is a progressive degenerative disease resulting in joint deterioration.
Synovial inflammation is present in the OA joint and has been associated with radiographic …

Emerging pharmaceutical therapies for osteoarthritis

A Latourte, M Kloppenburg, P Richette - Nature Reviews Rheumatology, 2020 - nature.com
The prevalence of osteoarthritis (OA) and the burden associated with the disease are
steadily increasing worldwide, representing a major public health challenge for the coming …

Synovitis in osteoarthritis: current understanding with therapeutic implications

A Mathiessen, PG Conaghan - Arthritis research & therapy, 2017 - Springer
Modern concepts of osteoarthritis (OA) have been forever changed by modern imaging
phenotypes demonstrating complex and multi-tissue pathologies involving cartilage …

Low-grade inflammation as a key mediator of the pathogenesis of osteoarthritis

WH Robinson, CM Lepus, Q Wang, H Raghu… - Nature Reviews …, 2016 - nature.com
Osteoarthritis (OA) has long been viewed as a degenerative disease of cartilage, but
accumulating evidence indicates that inflammation has a critical role in its pathogenesis …

Effect of intra-articular triamcinolone vs saline on knee cartilage volume and pain in patients with knee osteoarthritis: a randomized clinical trial

TE McAlindon, MP LaValley, WF Harvey, LL Price… - Jama, 2017 - jamanetwork.com
Importance Synovitis is common and is associated with progression of structural
characteristics of knee osteoarthritis. Intra-articular corticosteroids could reduce cartilage …

Mechanisms of osteoarthritis (OA) pain

TW O'Neill, DT Felson - Current osteoporosis reports, 2018 - Springer
Abstract Purpose of Review Osteoarthritis (OA) is a major cause of pain and disability
worldwide. There is, however, a relatively poor correlation between the severity of OA based …

Exosomes: roles and therapeutic potential in osteoarthritis

Z Ni, S Zhou, S Li, L Kuang, H Chen, X Luo, J Ouyang… - Bone research, 2020 - nature.com
Exosomes participate in many physiological and pathological processes by regulating cell–
cell communication, which are involved in numerous diseases, including osteoarthritis (OA) …

[HTML][HTML] Attenuation of early phase inflammation by cannabidiol prevents pain and nerve damage in rat osteoarthritis

HT Philpott, M O'Brien, JJ McDougall - Pain, 2017 - journals.lww.com
Osteoarthritis (OA) is a multifactorial joint disease, which includes joint degeneration,
intermittent inflammation, and peripheral neuropathy. Cannabidiol (CBD) is a noneuphoria …

Osteoarthritis: the genesis of pain

K Fu, SR Robbins, JJ McDougall - Rheumatology, 2018 - academic.oup.com
OA is a painful joint disease that predominantly affects the elderly. Pain is the primary
symptom of OA, and it can present as either intermittent or constant. OA pain mechanisms …

[HTML][HTML] Osteoarthritis: a disease of the joint as an organ

RF Loeser, SR Goldring, CR Scanzello… - Arthritis and …, 2012 - ncbi.nlm.nih.gov
Osteoarthritis (OA) is the most common form of arthritis and a major cause of pain and
disability in older adults (1). Often OA is referred to as degenerative joint disease “(DJD)” …