The assembly of a functional kinetochore on centromeric chromatin is necessary to connect
chromosomes to the mitotic spindle, ensuring accurate chromosome segregation. This …

The point centromere of budding yeast specifies assembly of the large kinetochore complex
to mediate chromatid segregation. Kinetochores comprise the centromere-associated inner …

Mitotic division maintains genetic identity of any multicellular organism throughout an entire
lifetime. Each time a parent cell divides, chromosomes are equally distributed between the …

The essential functions required for mitotic spindle assembly and chromosome biorientation
and segregation are not fully understood, despite extensive study. To illuminate the …

Proper chromosome segregation is crucial for cell division. In eukaryotes, this is achieved by
the kinetochore, an evolutionarily conserved multiprotein complex that physically links the …

Chromosome segregation depends on the kinetochore, the machine that establishes force-
bearing attachments between DNA and spindle microtubules. Kinetochores are formed …

Conserved proteins drive clathrin-mediated endocytosis (CME), which from yeast to humans
involves a burst of actin assembly. To gain mechanistic insights into this process, we …

Accurate segregation of chromosomes to daughter cells is a critical aspect of cell division. It
requires the kinetochores on duplicated chromosomes to biorient, attaching to microtubules …

Kinetochores are supramolecular assemblies that link centromeres to microtubules for sister
chromatid segregation in mitosis. For this, the inner kinetochore CCAN/Ctf19 complex binds …

In dividing cells, depolymerizing spindle microtubules move chromosomes by pulling at their
kinetochores. While kinetochore subcomplexes have been studied extensively in vitro, little …