Discovery and validation of biomarkers to aid the development of safe and effective pain therapeutics: challenges and opportunities

KD Davis, N Aghaeepour, AH Ahn, MS Angst… - Nature Reviews …, 2020 - nature.com
Pain medication plays an important role in the treatment of acute and chronic pain
conditions, but some drugs, opioids in particular, have been overprescribed or prescribed …

Recent developments in sample preparation techniques combined with high-performance liquid chromatography: A critical review

AB Kanu - Journal of Chromatography A, 2021 - Elsevier
This review article compares and contrasts sample preparation techniques coupled with
high-performance liquid chromatography (HPLC) and describes applications developed in …

Precision medicine: disease subtyping and tailored treatment

RC Wang, Z Wang - Cancers, 2023 - mdpi.com
Simple Summary The genomics-based concept of precision medicine began to emerge
following the completion of the Human Genome Project. In contrast to evidence-based …

Mass spectrometry-based metabolomics in health and medical science: A systematic review

X Zhang, Q Li, J Dou - RSC advances, 2020 - pubs.rsc.org
Metabolomics is the study of the investigation of small molecules derived from cellular and
organism metabolism, which reflects the outcomes of the complex network of biochemical …

Nuclear magnetic resonance spectroscopy in clinical metabolomics and personalized medicine: current challenges and perspectives

MPM Letertre, P Giraudeau, P De Tullio - Frontiers in Molecular …, 2021 - frontiersin.org
Personalized medicine is probably the most promising area being developed in modern
medicine. This approach attempts to optimize the therapies and the patient care based on …

Metabolomics in the Diagnosis and Prognosis of COVID-19

MR Hasan, M Suleiman, A Perez-Lopez - Frontiers in Genetics, 2021 - frontiersin.org
Coronavirus disease 2019 (COVID-19) pandemic triggered an unprecedented global effort
in developing rapid and inexpensive diagnostic and prognostic tools. Since the genome of …

Blueprint for cancer research: critical gaps and opportunities

LW Elmore, SF Greer, EC Daniels… - CA: A Cancer …, 2021 - Wiley Online Library
We are experiencing a revolution in cancer. Advances in screening, targeted and immune
therapies, big data, computational methodologies, and significant new knowledge of cancer …

Structure annotation of all mass spectra in untargeted metabolomics

I Blaženović, T Kind, MR Sa, J Ji, A Vaniya… - Analytical …, 2019 - ACS Publications
Urine metabolites are used in many clinical and biomedical studies but usually only for a few
classic compounds. Metabolomics detects vastly more metabolic signals that may be used to …

Combined nuclear magnetic resonance spectroscopy and mass spectrometry approaches for metabolomics

MPM Letertre, G Dervilly, P Giraudeau - Analytical chemistry, 2020 - ACS Publications
Metabolomics is based on cutting-edge analytical methods that provide a “snapshot” of all
the detectable metabolites, small molecules generally weighing under 1200 Da, present in …

Current state and challenges of the global outcomes of dental caries research in the meta-omics era

DG Moussa, P Ahmad, TA Mansour… - Frontiers in Cellular and …, 2022 - frontiersin.org
Despite significant healthcare advances in the 21st century, the exact etiology of dental
caries remains unsolved. The past two decades have witnessed a tremendous growth in our …