The NOTCH gene was identified approximately 110 years ago. Classical studies have
revealed that NOTCH signaling is an evolutionarily conserved pathway. NOTCH receptors …

Ongoing research has revealed that the existence of cancer stem cells (CSCs) is one of the
biggest obstacles in the current cancer therapy. CSCs make an influential function in tumor …

Abstract NOTCH1, NOTCH2, NOTCH3 and NOTCH4 are transmembrane receptors that
transduce juxtacrine signals of the delta‑like canonical Notch ligand (DLL) 1, DLL3, DLL4 …

Notch signaling pathway is evolutionarily conserved in mammals, which plays an important
role in cell development and differentiation. In recent years, increasing evidence has shown …

Aberrant activation of Notch signaling plays an oncogenic role in cancer development.
Jagged1 (JAG1) is an important Notch ligand that triggers Notch signaling through cell-cell …

Papillary renal cell carcinoma (pRCC) is the most heterogenous renal cell carcinoma.
Patient survival varies and no effective therapies for advanced pRCC exist. Histological and …

Histone deacetylases (HDACs) are epigenetic enzymes which participate in transcriptional
repression and chromatin condensation mechanisms by removing the acetyl moiety from …

Tumor heterogeneity poses one of the greatest challenges to a successful treatment of
cancer. Tumor cell populations consist of different subpopulations that have distinct …

Acute tissue injury causes DNA damage and repair processes involving increased cell
mitosis and polyploidization, leading to cell function alterations that may potentially drive …

Aims As a fifth most common cancer type, Hepatocellularcarcinoma (HCC) ranked third
leading cause of cancer deaths worldwide. Arsenic trioxide (As 2 O 3) is known as …