Viral strategies for targeting the central and peripheral nervous systems
CN Bedbrook, BE Deverman… - Annual review of …, 2018 - annualreviews.org
Recombinant viruses allow for targeted transgene expression in specific cell populations
throughout the nervous system. The adeno-associated virus (AAV) is among the most …
throughout the nervous system. The adeno-associated virus (AAV) is among the most …
AAV targeting of glial cell types in the central and peripheral nervous system and relevance to human gene therapy
Different glial cell types are found throughout the central (CNS) and peripheral nervous
system (PNS), where they have important functions. These cell types are also involved in …
system (PNS), where they have important functions. These cell types are also involved in …
Engineered AAVs for efficient noninvasive gene delivery to the central and peripheral nervous systems
Adeno-associated viruses (AAVs) are commonly used for in vivo gene transfer.
Nevertheless, AAVs that provide efficient transduction across specific organs or cell …
Nevertheless, AAVs that provide efficient transduction across specific organs or cell …
Neuronal programming by microbiota regulates intestinal physiology
Neural control of the function of visceral organs is essential for homeostasis and health.
Intestinal peristalsis is critical for digestive physiology and host defence, and is often …
Intestinal peristalsis is critical for digestive physiology and host defence, and is often …
Adrenergic signaling in muscularis macrophages limits infection-induced neuronal loss
Enteric-associated neurons (EANs) are closely associated with immune cells and
continuously monitor and modulate homeostatic intestinal functions, including motility and …
continuously monitor and modulate homeostatic intestinal functions, including motility and …
Dedicated macrophages organize and maintain the enteric nervous system
Correct development and maturation of the enteric nervous system (ENS) is critical for
survival. At birth, the ENS is immature and requires considerable refinement to exert its …
survival. At birth, the ENS is immature and requires considerable refinement to exert its …
Widespread central nervous system gene transfer and silencing after systemic delivery of novel AAV-AS vector
Effective gene delivery to the central nervous system (CNS) is vital for development of novel
gene therapies for neurological diseases. Adeno-associated virus (AAV) vectors have …
gene therapies for neurological diseases. Adeno-associated virus (AAV) vectors have …
Regional complexity in enteric neuron wiring reflects diversity of motility patterns in the mouse large intestine
Z Li, MM Hao, C Van den Haute, V Baekelandt… - Elife, 2019 - elifesciences.org
The enteric nervous system controls a variety of gastrointestinal functions including intestinal
motility. The minimal neuronal circuit necessary to direct peristalsis is well-characterized but …
motility. The minimal neuronal circuit necessary to direct peristalsis is well-characterized but …
In vivo selection yields AAV-B1 capsid for central nervous system and muscle gene therapy
SR Choudhury, Z Fitzpatrick, AF Harris, SA Maitland… - Molecular Therapy, 2016 - cell.com
Adeno-associated viral (AAV) vectors have shown promise as a platform for gene therapy of
neurological disorders. Achieving global gene delivery to the central nervous system (CNS) …
neurological disorders. Achieving global gene delivery to the central nervous system (CNS) …
Schizophrenia, the gut microbiota, and new opportunities from optogenetic manipulations of the gut-brain axis
Schizophrenia research arose in the twentieth century and is currently rapidly developing,
focusing on many parallel research pathways and evaluating various concepts of disease …
focusing on many parallel research pathways and evaluating various concepts of disease …